ITPR3
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 6: 33.62 – 33.7 Mb | Chr 17: 27.28 – 27.34 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a
inositol triphosphate and a calcium channel.[6]
Function
ITP3 channels serve an important role in the taste transduction pathway of
gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000096433 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042644 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: inositol 1".
- PMID 8081734.
- PMID 20696704.
Further reading
- Kline CF, Cunha SR, Lowe JS, et al. (2008). "Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor". J. Cell. Biochem. 104 (4): 1244–53. PMID 18275062.
- Oishi T, Iida A, Otsubo S, et al. (2008). "A functional SNP in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus in Japanese population". J. Hum. Genet. 53 (2): 151–62. PMID 18219441.
- Hirose M, Stuyvers B, Dun W, et al. (2008). "Wide long lasting perinuclear Ca2+ release events generated by an interaction between ryanodine and IP3 receptors in canine Purkinje cells". J. Mol. Cell. Cardiol. 45 (2): 176–84. PMID 18586264.
- Miyachi K, Iwai M, Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases". Mod Rheumatol. 17 (2): 137–43. S2CID 36516047.
- Tang TS, Guo C, Wang H, et al. (2009). "Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a Huntington's disease mouse model". J. Neurosci. 29 (5): 1257–66. PMID 19193873.
- Nagaleekar VK, Diehl SA, Juncadella I, et al. (2008). "IP3 receptor-mediated Ca2+ release in naive CD4 T cells dictates their cytokine program". J. Immunol. 181 (12): 8315–22. PMID 19050248.
- Bandyopadhyay BC, Swaim WD, Liu X, et al. (2005). "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx". J. Biol. Chem. 280 (13): 12908–16. PMID 15623527.
- Kasri NN, Holmes AM, Bultynck G, et al. (2004). "Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins". EMBO J. 23 (2): 312–21. PMID 14685260.
- Hattori M, Suzuki AZ, Higo T, et al. (2004). "Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling". J. Biol. Chem. 279 (12): 11967–75. PMID 14707143.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.
- Roach JC, Deutsch K, Li S, et al. (2006). "Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden". Am. J. Hum. Genet. 79 (4): 614–27. PMID 16960798.
- Tojyo Y, Morita T, Nezu A, Tanimura A (2008). "The clustering of inositol 1,4,5-trisphosphate (IP(3)) receptors is triggered by IP(3) binding and facilitated by depletion of the Ca2+ store". J. Pharmacol. Sci. 107 (2): 138–50. PMID 18544901.
- Singleton PA, Bourguignon LY (2004). "CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation". Exp. Cell Res. 295 (1): 102–18. PMID 15051494.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Ogasawara H (2008). "The calcium kinetics and inositol trisphosphate receptor properties shape the asymmetric timing window of coincidence detection". J. Neurosci. 28 (17): 4293–4. PMID 18434505.
- Qu HQ, Marchand L, Szymborski A, et al. (2008). "The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II". Genes Immun. 9 (3): 264–6. S2CID 8563179.
- Wu Z, Bowen WD (2008). "Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells". J. Biol. Chem. 283 (42): 28198–215. PMID 18539593.
- Martínez-Gámez A, Dent MA (2007). "Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve". NeuroReport. 18 (5): 447–50. S2CID 28136973.
- Garcia-Elias A, Lorenzo IM, Vicente R, Valverde MA (2008). "IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site". J. Biol. Chem. 283 (46): 31284–8. PMID 18826956.
- Sundivakkam PC, Kwiatek AM, Sharma TT, et al. (2009). "Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells". Am. J. Physiol., Cell Physiol. 296 (3): C403–13. PMID 19052258.
External links
- ITPR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |