TRPV3
| TRPV3 | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 17: 3.51 – 3.56 Mb | Chr 11: 73.16 – 73.19 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human gene encoding the protein of the same name.
The TRPV3 protein belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of human sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels.[5]
Function
The TRPV3 channel has wide tissue expression that is especially high in the
Modulation
The TRPV3 channel is directly activated by various natural compounds like
Resolvin E1 (RvE1), RvD2, and 17R-RvD1 (see
Ligands
Agonists
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167723 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043029 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: TRPV3 transient receptor potential cation channel, subfamily V, member 3".
- S2CID 6180133.
- S2CID 11504772.
- PMID 17888882.
- ^ "Incense on the brain, by Ran Shapira, Haaretz". Haaretz.
- PMID 22284622.
- S2CID 13088422.
- PMID 17420775.
- PMID 19470296.
- S2CID 10160642.
- PMID 25359497.
- PMID 26339646.
- PMID 21963090.
- PMID 25857211.
- PMID 15175387.
- PMID 25089200.
- PMID 22548000.
- PMID 30377214.
- PMID 20395302.
- PMID 18492727.
- PMID 27077528.
Further reading
- Islam MS (January 2011). Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology. Vol. 704. Berlin: Springer. p. 700. ISBN 978-94-007-0264-6.
- Clapham DE, Julius D, Montell C, Schultz G (2006). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. S2CID 17936350.
External links
- TRPV3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.