GDF10
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| Location (UCSC) | Chr 10: 47.3 – 47.31 Mb | Chr 14: 33.65 – 33.66 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.[5]
GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.[5][6] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.[5]
In mice, GDF10 mRNA is abundant in the
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000266524 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021943 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 8679252.
- PMID 14977563.
- PMID 16596286.
Further reading
- Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. PMID 20237496.
- Ducy P, Karsenty G (2000). "The family of bone morphogenetic proteins". Kidney Int. 57 (6): 2207–14. PMID 10844590.
- Grupe A, Li Y, Rowland C, et al. (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. PMID 16385451.
- Hino J, Takao M, Takeshita N, et al. (1996). "cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b)". Biochem. Biophys. Res. Commun. 223 (2): 304–10. PMID 8670277.
- Zhou M, Lucas DA, Chan KC, et al. (2004). "An investigation into the human serum "interactome"". Electrophoresis. 25 (9): 1289–98. S2CID 42449980.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Kimura K, Toyooka S, Tsukuda K, et al. (2008). "The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas". Oncol. Rep. 20 (5): 1265–8. PMID 18949431.
- Lafont JE, Talma S, Hopfgarten C, Murphy CL (2008). "Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways". J. Biol. Chem. 283 (8): 4778–86. PMID 18077449.