Mothers against decapentaplegic homolog 9

SMAD9
Identifiers
Gene ontology
Molecular function	DNA binding DNA-binding transcription factor activity metal ion binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	SMAD protein complex transcription regulator complex intracellular anatomical structure nucleoplasm nucleus cytoplasm cytosol
Biological process	ureteric bud development regulation of transcription, DNA-templated SMAD protein signal transduction cellular response to organic cyclic compound hindbrain development cellular response to BMP stimulus BMP signaling pathway transcription, DNA-templated protein phosphorylation cartilage development bone development transforming growth factor beta receptor signaling pathway midbrain development positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
Sources:Amigo / QuickGO

Ensembl				ENSG00000120693	ENSMUSG00000027796
UniProt	O15198	Q9JIW5
RefSeq (mRNA)	NM_001127217 NM_005905 NM_001378621	NM_019483
RefSeq (protein)	NP_001120689 NP_005896 NP_001365550	NP_062356
Location (UCSC)	Chr 13: 36.84 – 36.92 Mb	Chr 3: 54.66 – 54.71 Mb
PubMed search	[3]	[4]

Wikidata

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Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the SMAD9 gene.^[5]

SMAD9, as its name describes, is a homolog of the

of the protein. Confusingly, it is also sometimes referred to as SMAD8 in the literature.

Nomenclature

The SMAD proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The name is a combination of the two. During Drosophila research, it was found that a mutation in the gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo. The phrase "Mothers against" was added since mothers often form organizations opposing various issues e.g. Mothers Against Drunk Driving or (MADD); and based on a tradition of such unusual naming within the gene research community.^[6]

References