Mothers against decapentaplegic homolog 1
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| Location (UCSC) | n/a | Chr 8: 80.07 – 80.13 Mb | |||||||
| PubMed search | [2] | [3] | |||||||
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Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.[4][5]
Nomenclature
SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma.[citation needed] The name is a combination of the two; and based on a tradition of such unusual naming within the gene research community.[6]
It was found that a mutation in the 'Drosophila' gene, MAD, in the mother, repressed the gene, decapentaplegic, in the embryo. Mad mutations can be placed in an allelic series based on the relative severity of the maternal effect enhancement of weak dpp alleles, thus explaining the name Mothers against dpp.[7]
Function
SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the
SMAD1 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase.
References
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031681 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 2275955.
- S2CID 10124489.
- ^ "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White. psmag.com
- ^ "Interactive fly, Drosophila".
- ^ "Entrez Gene: SMAD1 SMAD family member 1".
External links
- Drosophila Mothers against dpp - The Interactive Fly
- Smad1+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- SMAD1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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