Hydroxyacyl-Coenzyme A dehydrogenase
| HADH | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 4: 107.99 – 108.04 Mb | Chr 3: 131.03 – 131.07 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Hydroxyacyl-Coenzyme A dehydrogenase (HADH) is an enzyme which in humans is encoded by the HADH gene.[5][6]
Structure
The HADH gene is located on the 4th
Function
This gene is a member of the
Clinical significance
Mutations in this gene cause one form of familial
brain damage.[11]
Interactions
HADH has been shown to interact with Vpr, such that HIV-1 Vpr regulates mitochondrial respiration and enhances the activity of hydroxyacyl-CoA dehydrogenase (HADH) through PPARbeta/delta.[13]
See also
- 3-hydroxyacyl-CoA dehydrogenase
- hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000138796 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027984 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 975867.
- S2CID 45683141.
- ^ a b "Entrez Gene: HADH".
- PMID 23965338.
- ^ "Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 2015-09-24. Retrieved 2015-03-23.
- PMID 14693719.
- ^ S2CID 36618116.
- PMID 23273570.
- PMID 23842279.
External links
- GeneReviews/NCBI/NIH/UW entry on Familial Hyperinsulinism
- Overview of all the structural information available in the PDB for UniProt: Q16836 (Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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