Jeffrey I. Gordon

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Jeffrey Ivan Gordon
Bornc. 1947 (age 76–77)
NationalityAmerican
Alma materUniversity of Chicago
Oberlin College
AwardsCopley Medal (2018)
Balzan Prize (2021)
Scientific career
FieldsMedicine
InstitutionsWashington University in St. Louis

Jeffrey Ivan Gordon

Institute of Medicine of the National Academies, and the American Philosophical Society.[4]

Education and early career

Gordon received his bachelor's degree in Biology at 1969 at Oberlin College in Ohio. Over the next four years, Gordon received his medical training at the University of Chicago and graduated with honors in 1973. After two years as intern and junior assistant resident in Medicine at Barnes Hospital, St Louis, Gordon joined the Laboratory of Biochemistry at the National Cancer Institute as a Research Associate in 1975. He returned to Barnes Hospital in 1978 to become Senior Assistant Resident and then Chief Medical Resident at Washington University Medical Service. In 1981 he completed a fellowship in medicine (Gastroenterology) at Washington University School of Medicine. In the following years, Gordon rose quickly through the academic ranks at Washington University: Asst. Prof. (1981–1984); Assoc. Prof. (1985–1987); Prof. (1987–1991) of Medicine and Biological Chemistry. In 1991, he became head of the Dept. Molecular Biology & Pharmacology (1991–2004). Gordon is currently the Director of the Center for Genome Sciences (2004–present) at Washington University in St. Louis.

Gordon's early career focused on the development of cell lineages within the

multipotent stem cells
.

Gordon played a pivotal role in the study of protein N-myristoylation, a co-translational modification by which a myristoyl group is covalently attached to an N-terminal glycine residue of a nascent polypeptide. Gordon and his colleagues were instrumental in characterizing the mechanism by which N-myristoyltransferase (the enzyme that catalyzes the myristoylation reaction) selects its substrates and its catalytic mechanism.[5]

Gordon's group published a series of elegant studies that describe the ability of components of the commensal microbiota to induce specific responses in the host intestinal epithelium. One of these responses, the induction of intestinal cell surface fucose residues, is elicited by a prominent human intestinal symbiont, Bacteroides thetaiotaomicron, which can harvest and use the host fucose as a carbon and energy source.[6] Gordon's group published a seminal study in which functional genomics were used to document the genome-wide intestinal epithelial response to microbial colonization of the gastrointestinal tract.[7] Dr. Gordon's laboratory has investigated epithelial cell interaction with human-associated pathogens, including uropathogenic Escherichia coli, Helicobacter pylori, and Listeria monocytogenes.

Present research

Gordon and his laboratory are currently focused on understanding the mutualistic interactions that occur between humans and the 10–100 trillion commensal microbes that colonize each person's gastrointestinal tract. To tease apart the complex relationships that exist within this gut microbiota, Dr. Gordon's research program employs

gnotobiotic
mice as model hosts, which may be colonized with defined, simplified microbial communities. These model intestinal microbiotas are more amenable to well-controlled experimentation.

Gordon has become an international pioneer in the study of gut microbial ecology and evolution, using innovative methods to interpret

gut microbiota plays a role in host fat storage and obesity.[8] Gordon and co-workers have used DNA pyrosequencing technology to perform metagenomics on the intestinal contents of obese mice, demonstrating that the gut microbiota of fat mice possess an enhanced capacity for aiding the host in harvesting energy from the diet.[9] A study of the microbial ecology of obese human subjects on two different weight loss diets indicate that the same principles may be operating in humans.[10] His group has applied the sequencing of bacterial and archaeal genomes to describe the microbial functional genomic and metabolomic underpinnings of microbial adaptation to the gastrointestinal habitat.[11][12] This approach has been extended to describe the role of the adaptive immune system in maintaining the host-microbial relationship.[13]

Gordon is the lead author of an influential 2005

Human Microbiome Project was listed on the NIH Roadmap for Medical Research as one of the New Pathways to Discovery.[14]

Selected honors

References

  1. ^ Akademien
  2. ^ "Lab of Jeffrey I. Gordon • 2017 • Washington University in St. Louis". Archived from the original on August 7, 2019. Retrieved September 30, 2011.
  3. ^ "Washington University News". Archived from the original on June 8, 2010. Retrieved February 19, 2008.
  4. ^ "APS Member History". search.amphilsoc.org. Retrieved March 12, 2021.
  5. ISSN 0021-9258
    .
  6. S2CID 39804775
    .
  7. PMID 11157169
    .
  8. PMID 17210919
    .
  9. S2CID 4400297
    .
  10. S2CID 205034045
    .
  11. S2CID 13588903
    .
  12. PMID 17563350
    .
  13. PMID 18005754
    .
  14. ^ NIH Roadmap Archived December 10, 2010, at the Wayback Machine
  15. ^ a b "Gordon CV". Lab of Jeffrey I. Gordon. June 26, 2020. Retrieved February 23, 2021.
  16. ^ "Jeffrey I. Gordon". www.balzan.org. Retrieved April 13, 2022.
  17. ^ Princess of Asturias Awards 2023
  18. ^ Albany Medical Center Prize 2023

External links

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