Leucyl/cystinyl aminopeptidase
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Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene.[5][6]
This gene encodes a zinc-dependent
hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]
Mutations in this gene have been associated to psoriasis risk.(doi:10.1038/jid.2013.317)
Interactions
Cystinyl aminopeptidase has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000113441 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023845 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8550619.
- ^ a b "Entrez Gene: LNPEP leucyl/cystinyl aminopeptidase".
- PMID 12080061.
- PMID 10988299.
- PMID 11802774.
Further reading
- Albiston AL, Mustafa T, McDowall SG, et al. (2003). "AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement". Trends Endocrinol. Metab. 14 (2): 72–7. S2CID 6481079.
- Keller SR (2004). "The insulin-regulated aminopeptidase: a companion and regulator of GLUT4". Front. Biosci. 8 (6): s410–20. PMID 12700100.
- Keller SR (2005). "Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes". Biol. Pharm. Bull. 27 (6): 761–4. PMID 15187412.
- Nomura S, Ito T, Yamamoto E, et al. (2005). "Gene regulation and physiological function of placental leucine aminopeptidase/oxytocinase during pregnancy". Biochim. Biophys. Acta. 1751 (1): 19–25. PMID 15894523.
- Tsujimoto M, Hattori A (2005). "The oxytocinase subfamily of M1 aminopeptidases". Biochim. Biophys. Acta. 1751 (1): 9–18. PMID 16054015.
- Mizutani S, Shibata K, Kikkawa F, et al. (2007). "Essential role of placental leucine aminopeptidase in gynecologic malignancy". Expert Opin. Ther. Targets. 11 (4): 453–61. S2CID 42839602.
- Tsujimoto M, Mizutani S, Adachi H, et al. (1992). "Identification of human placental leucine aminopeptidase as oxytocinase". Arch. Biochem. Biophys. 292 (2): 388–92. PMID 1731608.
- Mizutani S, Akiyama H, Kurauchi O, et al. (1985). "In vitro degradation of angiotensin II (A-II) by human placental subcellular fractions, pregnancy sera and purified placental aminopeptidases". Acta Endocrinol. 110 (1): 135–9. PMID 3898693.
- Beckman L, Björling G, Christodoulou C (1966). "Pregnancy enzymes and placental polymorphism. II. Leucine aminopeptidase". Acta Genetica et Statistica Medica. 16 (2): 122–31. PMID 5953194.
- Itoh C, Watanabe M, Nagamatsu A, et al. (1997). "Two molecular species of oxytocinase (L-cystine aminopeptidase) in human placenta: purification and characterization". Biol. Pharm. Bull. 20 (1): 20–4. PMID 9013800.
- Laustsen PG, Rasmussen TE, Petersen K, et al. (1997). "The complete amino acid sequence of human placental oxytocinase". Biochim. Biophys. Acta. 1352 (1): 1–7. PMID 9177475.
- Nagasaka T, Nomura S, Okamura M, et al. (1998). "Immunohistochemical localization of placental leucine aminopeptidase/oxytocinase in normal human placental, fetal and adult tissues". Reprod. Fertil. Dev. 9 (8): 747–53. PMID 9733056.
- Horio J, Nomura S, Okada M, et al. (1999). "Structural organization of the 5'-end and chromosomal assignment of human placental leucine aminopeptidase/insulin-regulated membrane aminopeptidase gene". Biochem. Biophys. Res. Commun. 262 (1): 269–74. PMID 10448104.
- Rasmussen TE, Pedraza-Díaz S, Hardré R, et al. (2000). "Structure of the human oxytocinase/insulin-regulated aminopeptidase gene and localization to chromosome 5q21". Eur. J. Biochem. 267 (8): 2297–306. PMID 10759854.
- Nakanishi Y, Nomura S, Okada M, et al. (2001). "Immunoaffinity purification and characterization of native placental leucine aminopeptidase/oxytocinase from human placenta". Placenta. 21 (7): 628–34. PMID 10985965.
- Chi NW, Lodish HF (2001). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. 275 (49): 38437–44. PMID 10988299.
- Matsumoto H, Nagasaka T, Hattori A, et al. (2001). "Expression of placental leucine aminopeptidase/oxytocinase in neuronal cells and its action on neuronal peptides". Eur. J. Biochem. 268 (11): 3259–66. PMID 11389728.
- Iwase A, Nomura S, Mizutani S (2001). "Characterization of a secretase activity for placental leucine aminopeptidase". Arch. Biochem. Biophys. 393 (1): 163–9. PMID 11516173.
- Ito T, Nomura S, Okada M, et al. (2001). "Transcriptional regulation of human placental leucine aminopeptidase/oxytocinase gene". Mol. Hum. Reprod. 7 (9): 887–94. PMID 11517297.
External links
- The MEROPS online database for peptidases and their inhibitors: M01.011
- Cystinyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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