Lomefloxacin

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Lomefloxacin
Clinical data
Trade namesMaxaquin
AHFS/Drugs.comConsumer Drug Information
MedlinePlusa600002
ATC code
Pharmacokinetic data
Protein binding10%
Elimination half-life8 hours[1]
Identifiers
  • (RS)-1-Ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid
JSmol)
Melting point239 to 240.5 °C (462.2 to 464.9 °F)
  • Fc1c(c(F)c2c(c1)C(=O)C(\C(=O)O)=C/N2CC)N3CC(NCC3)C
  • InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) checkY
  • Key:ZEKZLJVOYLTDKK-UHFFFAOYSA-N checkY
  (verify)

Lomefloxacin hydrochloride (sold under the following brand names in English-speaking countries Maxaquin, Okacyn, Uniquin) is a

fluoroquinolone antibiotic used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. Lomefloxacin is associated with phototoxicity and central nervous system adverse effects.[2]

In October 2008, the

chelate
with itself. The chelate is formed between the 2-carbonyl group of two separate lomefloxacin molecules."

It was patented in 1983 and approved for medical use in 1989.[3]

References

  1. PMID 28431777
    . Lomefloxacin elimination half-life is about 7–8 h and is prolonged in patients with renal impairment.
  2. S2CID 21890070
    .
  3. ISBN 9783527607495
    .
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