Nemonoxacin

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Nemonoxacin
Names
Preferred IUPAC name
7-[(3S,5S)-3-Amino-5-methylpiperidin-1-yl]-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
DrugBank
IUPHAR/BPS
UNII
  • InChI=1S/C20H25N3O4/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26)/t11-,12-/m0/s1
    Key: AVPQPGFLVZTJOR-RYUDHWBXSA-N
  • InChI=1/C20H25N3O4/c1-11-7-12(21)9-22(8-11)16-6-5-14-17(19(16)27-2)23(13-3-4-13)10-15(18(14)24)20(25)26/h5-6,10-13H,3-4,7-9,21H2,1-2H3,(H,25,26)/t11-,12-/m0/s1
    Key: AVPQPGFLVZTJOR-RYUDHWBXBZ
  • C[C@H]1C[C@H](N)CN(C1)c2ccc3c(c2OC)n(C4CC4)cc(c3=O)C(=O)O
Properties
C20H25N3O4
Molar mass 371.437 g·mol−1
Pharmacology
J01MB08 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Nemonoxacin is a non-fluorinated

acute bacterial skin and skin-structure infections (ABSSSI).[5]

Nemonoxacin has a broad spectrum of activity against

C.difficile isolates that are resistant to other quinolones,[9] and is more potent than levofloxacin or moxifloxacin.[10]

References

  1. S2CID 34452344
    .
  2. ^ "TaiGen releases Taigexyn (nemonoxacin) capsules in Taiwan". 16 December 2015.
  3. ^ Biotechnology T. "TaiGen Biotechnology Out-Licenses Taigexyn® (Nemonoxacin) to Productos Científicos for the Latin American Market" (Press release).
  4. ^ "A Phase III Study to Evaluate the Efficacy and Safety of Intravenous Infusion of Nemonoxacin in Treating CAP - Full Text View - ClinicalTrials.gov". 22 October 2021.
  5. ^ "FDA grants QIDP and Fast Track designations to TaiGen's nemonoxacin". 23 December 2013.
  6. PMID 20065058
    .
  7. PMID 19738018
    .
  8. PMID 20660689
    .
  9. PMID 22508299
    .
  10. PMID 23587953
    .


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