Mannitol-1-phosphate 5-dehydrogenase
mannitol-1-phosphate 5-dehydrogenase | |||||||||
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Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In
enzymology, a mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) is an enzyme that catalyzes the chemical reaction
- D-mannitol 1-phosphate + NAD+ D-fructose 6-phosphate + NADH + H+
Thus, the two
substrates of this enzyme are D-mannitol 1-phosphate and NAD+, whereas its 3 products are fructose 6-phosphate, NADH and H+
.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-mannitol-1-phosphate:NAD+ 2-oxidoreductase. Other names in common use include hexose reductase, mannitol 1-phosphate dehydrogenase, D-mannitol-1-phosphate dehydrogenase, and fructose 6-phosphate reductase. This enzyme participates in fructose and mannose metabolism.
See also
- D-Mannitol
References
- Marmur J, Hotchkiss RD (1955). "Mannitol metabolism, a transferable property of pneumococcus". J. Biol. Chem. 214 (1): 383–96. PMID 14367396.
- Wolfe JB; Kaplan NO (1955). Wolff, Johnb; Kaplan, Nathano (eds.). "Hexose phosphate and hexose reductase. A. D-Mannitol-1-phosphate dehydrogenase from E. coli". Methods Enzymol. 1: 346–348. .
- Wolfe JB; Kaplan NO (1956). "D-Mannitol 1-phosphate dehydrogenase from Escherichia coli". J. Biol. Chem. 218: 849–869. PMID 13295236.