Milbemycin oxime
 | ||
| Clinical data | ||
|---|---|---|
| Trade names | Interceptor | |
| License data | ||
QP54AB01 (WHO) | ||
| Legal status | ||
| Legal status | ||
ECHA InfoCard | 100.205.451 | |
| Chemical and physical data | ||
| Formula | C31H43NO7 (30%) C32H45NO7 (70%) | |
| Molar mass | 541.68 g/mol (30%) 555.702 g/mol (70%) | |
  (what is this?) (verify) | ||
Milbemycin oxime, sold under the brand name Interceptor among others, is a
miticide).[2]
Mechanism of action
Milbemycins are products of
myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer.[3]
Uses
Milbemycin oxime is active against a broad spectrum of
heartworm in dogs and cats,[4] although it is less potent against heartworms than ivermectin.[citation needed
]
The substance is often combined with other parasiticides to achieve a broader spectrum of action. Such products include:[citation needed]
- Milbemax and Interceptor Plus (with praziquantel)
- Sentinel Flavor Tabs (with lufenuron)
- Trifexis (with spinosad)
- NexGard Spectra (with afoxolaner)
The drug has been used in marine reef aquaria to control parasitic Tegastidae copepod infestations on captive hard coral colonies. Other arthropod invertebrates will be killed by the treatment.[5][6]
Side effects
The drug is usually tolerated well, but such side effects may occur such as vomiting, phlegming, and glassy eyes.[citation needed]
References
- ^ a b c "Interceptor Flavor Tabs- milbemycin oxime tablet". DailyMed. Retrieved 4 August 2021.
- PMID 22488596.
- ISBN 978-3-540-48994-8.
- ^ "NADA 140-915 Interceptor – supplemental approval (September 9, 1996)". Food and Drug Administration.
- ISBN 978-1-119-94948-0.
- ISBN 978-0-470-96078-3.