Oxantel

Oxantel

QP52AF03 (WHO )
Identifiers
IUPAC name 3-[(E)-2-(1-Methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol
JSmol)	Interactive image
SMILES CN1CCCN=C1/C=C/C2=CC(=CC=C2)O
InChI InChI=1S/C13H16N2O/c1-15-9-3-8-14-13(15)7-6-11-4-2-5-12(16)10-11/h2,4-7,10,16H,3,8-9H2,1H3/b7-6+ N Key:VRYKTHBAWRESFI-VOTSOKGWSA-N N
NY (what is this?)  (verify)

Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms.^[1] It has also been shown to inhibit fumarate reductase in some pathogenic bacteria.^[2]

Similarly to pyrantel, oxantel depolarises the neurons of gastrointestinal parasites 100x more than acetylcholine, causing sustained muscular contraction, causing the parasites to die by spastic paralysis. This anthelmintic is commonly used to treat domestic animals as well as livestock, and resistance has been reported in both groups of animals.^[3]

References