Selamectin
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Trade names | Revolution, Stronghold, Revolt |
Other names | 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22,23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide[1] |
AHFS/Drugs.com | International Drug Names |
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QP53BX55 (WHO) | |
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Selamectin, sold under the brand name Revolution, among others, is a
Veterinary uses
Selamectin is applied topically.[2] It is not miscible in water.[2]
Mode of action
Selamectin disables
The substance fights both internal and surface parasitic
Side effects
Selamectin has been found to be safe and effective in a 2003 review.[3]
Selamectin has high safety ratings, with less than 1% of pets displaying side effects[citation needed]. In cases where side-effects do occur, they most often include passing irritation or hair loss at the application site. Symptoms beyond these (such as drooling, rapid breathing, lack of coordination, vomiting, or diarrhea) could be due to shock as a result of selamectin killing heartworms or other vulnerable parasites present at high levels in the bloodstreams of dogs.[citation needed] This would be a reaction due to undetected or underestimated infections prior to using the medication, rather than an actual allergic reaction to the drug itself.[citation needed]
Society and culture
Brand names
Selamectin is sold under various brand names including Selehold, manufactured by KRKA, Selarid manufactured by Norbrook Laboratories Limited, Revolution and Stronghold manufactured by Zoetis, Revolt manufactured by Aurora Pharmaceuticals, and Senergy manufactured by Virbac.
Similar products
Main rival products for dogs include ivermectin (trade names Stromectol, Ivermec and others) or milbemycin oxime (Interceptor) for heartworms, imidacloprid and moxidectin (Advocate), fipronil (Frontline) or lufenuron (Program) for fleas, or the combination milbemycin oxime/lufenuron (Sentinel) for both.[citation needed]
References
- PMID 10940519.
- ^ a b c d "Revolution- selamectin solution". DailyMed. 1 December 2023. Retrieved 6 February 2024.
- ^ Pipano E (2003). "Recent Developments In The Control Of Ectoparasites And Endoparasites Of Dogs And Cats With Selamectin". Israel Journal of Veterianry Medicine. 58 (2–3). Archived from the original on April 14, 2008. Retrieved 2008-07-05.