Tribendimidine

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Tribendimidine
Clinical data
ATC code
  • none
Identifiers
  • N,N-bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4
    -phenylene dimethylidyneamine
JSmol)
  • N(=C/c2ccc(\C=N\c1ccc(/N=C(/N(C)C)C)cc1)cc2)\c3ccc(\N=C(\N(C)C)C)cc3
  • InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3/b29-19+,30-20+,31-21+,32-22+ checkY
  • Key:XOIOGKHKNQYULW-HTNNXBMUSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Tribendimidine is a broad-spectrum anthelmintic agent developed in China, at the National Institute of Parasitic Diseases in Shanghai. It is a derivative of amidantel.[1]

In

enterobiasis.[2] It is also effective against clonorchiasis.[3] However, animal studies suggest it is ineffective in treating Schistosoma mansoni or Fasciola hepatica disease.[1] The drug has also performed well in trials against opisthorchiasis, curing about 70% of cases.[4]

Tribendimidine is manufactured by Shandong Xinhua Pharmaceutical Company Limited in Zibo, Shandong, China. It was approved by the China Food and Drug Administration in 2007.[citation needed]

References

  1. ^
    PMID 17194822. Free full text
    .
  2. PMID 15777691
    .
  3. PMID 31542370
    .
  4. ^ Kelland K (2010-11-24). "New drug shows promise against Asian liver fluke". Reuters.
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