ORF10
| Orf10 protein, SARS-CoV-2 | |
|---|---|
| Identifiers | |
| Symbol | Orf10_SARS-CoV-2 |
| InterPro | IPR044342 |
ORF10 is an
positive selection.[3] However, although it is sometimes included in lists of SARS-CoV-2 accessory genes, experimental and bioinformatics evidence suggests ORF10 is likely not a functional protein-coding gene.[4]
Properties
ORF10 is located downstream of the N gene, which encodes
3' end of the genome. It encodes a 38-amino acid hypothetical protein.[1]
Expression and function
It is unlikely that ORF10 is
cullin-RING ligase protein complex.[6] However, this interaction has been shown to be dispensable in in vitro studies of the viral life cycle.[7]
Evolution
Some studies of SARS-CoV-2 genomes have described ORF10 as likely to be functional and under
coronavirus 3' UTR pseudoknot region, a secondary structure known to be involved in genome replication.[4]
