ORF7a
| Betacoronavirus NS7A protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the SARS-coronavirus ORF7a accessory protein | |||||||||
| Identifiers | |||||||||
| Symbol | bCoV_NS7A | ||||||||
| Pfam | PF08779 | ||||||||
| InterPro | IPR014888 | ||||||||
| |||||||||
ORF7a (also known by several other names, including SARS coronavirus X4, SARS-X4, ORF7a, or U122)
Function
A number of possible functions for the ORF7a protein have been described. The primary function is thought to be immunomodulation and interferon antagonism. The protein is not essential for viral replication.[1]
Viral protein interactions
Studies in SARS-CoV suggest that the protein forms
Host effects
A number of interactions with host proteins and effects on
It has also been reported to induce apoptosis via a caspase dependent pathway.[1][7] Also, it contains a motif which has been demonstrated to mediate COPII dependent transport out of the endoplasmic reticulum, and the protein is targeted to the Golgi apparatus.[8]
In SARS-CoV-2, ORF7a protein has been described as an effective
Structure
The ORF7a protein is a
Post-translational modifications
The SARS-CoV-2 ORF7a protein has been reported to be
Expression and localization
Genomic organisation of isolate Wuhan-Hu-1, the earliest sequenced sample of SARS-CoV-2, indicating the location of ORF7a | |
| NCBI genome ID | 86693 |
|---|---|
| Genome size | 29,903 bases |
| Year of completion | 2020 |
| Genome browser (UCSC) | |
Along with the genes for other
Evolution
It is thought that
Many SARS-CoV-2 genomes have been sequenced throughout the
