Steroidogenic enzyme

• Steroid desmolases
  • Cholesterol side-chain cleavage enzyme (20,22-desmolase) – steroid synthesis
  • 17,20-Lyase (17,20-desmolase) – androgen synthesis
• Steroid hydroxylases
  • 11β-Hydroxylase
    – corticosteroid synthesis
  • 17α-Hydroxylase – androgen and glucocorticoid synthesis
  • 18-Hydroxylase
    (aldosterone synthase) – mineralocorticoid synthesis
  • 21-Hydroxylase – corticosteroid synthesis
  • 3
    ) – estrogen metabolism
• ketosteroid reductases
  )
  • 3α-Hydroxysteroid dehydrogenase – androgen, progestogen, and neurosteroid synthesis and metabolism
  • 3β-Hydroxysteroid dehydrogenase/Δ^5-4-isomerase (1, 2) – androgen, progestogen, and neurosteroid synthesis
  • 2
    ) – corticosteroid synthesis and metabolism
  • 15
    ) – androgen, estrogen, and progestogen synthesis and metabolism
  • 20α-Hydroxysteroid dehydrogenase
    – progestogen synthesis and metabolism
  • 20β-Hydroxysteroid dehydrogenase
    – progestogen synthesis and metabolism

• Steroid reductases
  • 5α-Reductase (1, 2, 3) – androgen and neurosteroid synthesis, progestogen metabolism
  • 5β-Reductase – androgen and progestogen metabolism, neurosteroid synthesis
• deconjugation
  )
  • UGT2Bs) – steroid metabolism^[6]
  • β-glucuronidase) – steroid synthesis^[7]
  • 2B1b) – steroid metabolism, neurosteroid synthesis^[8]
  • Steroid sulfatase – steroid synthesis, neurosteroid metabolism^[8]
• Others
  • Aromatase (estrogen synthetase) – estrogen synthesis

See also

• Inborn errors of steroid metabolism
• Steroidogenesis inhibitor

References