Talk:Genetic code

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Despite the variations that exist, the genetic codes used by all known forms of life on Earth are very similar. Since there are many possible genetic codes that are thought to have similar utility to the one used by Earth life, the theory of evolution suggests that the genetic code was established very early in the history of life and meta-analysis of transfer RNA suggest it was established soon after the formation of earth.

One can ask the question: is the genetic code completely random, just one set of codon-amino acid correspondences that happened to establish itself and be "frozen in" early in evolution, although functionally any of the many other possible transcription tables would have done just as well? Already a cursory look at the table shows patterns that suggest that this is not the case. For example, C in 2nd position of the codon yields amino acid residues that are small in size and moderate in

Until several weeks ago the codon table in this article looked like this:

An IP changed it to the following:

This was reverted a few times, until the IP (editing from 220.253.25.118) explained the change: "codons are not polar etc but amino acids are." In other words, the color scheme applies to the amino acids, not the codons, so the colored shading should not be applied to the codons themselves. I agree with this reasoning. The problems with this table are that (1) As noted above, it's very bulky, and (2) Consequently, it obscures the non-random nature of the genetic code – the tendency for single-base substitutions to result in codons with similar chemical properties. In the sandbox, 220.253.25.118 created a new table which I think combines the best features of both other tables: it does not apply color shading to the codons, it's compact, and the non-random nature of the code is readily apparent. I've applied minor tweaks to this table, and the result is below:

I'm not sure why 220.253.25.118 didn't incorporate this into the article, but if there's no objection I'd like to replace the current table with this one. Adrian J. Hunter^{(talk•contribs)} 11:21, 11 September 2010 (UTC)[reply]

Support. Looks like an improvement in the current (making trends more apparent and table less bulky) while still retaining the valid polarity concern of the IP. An alternative solution is to simply clearly state in the table legend or intro that the coloring refers to the amino acid polarity, not just "polarity". The IP-current and Adrian's improvements still make horizontal (second-base for constant first and third) trends harder to notice (though obviously no 2D table can alow all three base-positions' comparisons by adjacency). DMacks (talk) 15:55, 11 September 2010 (UTC)[reply]

I see what you mean about the second base trends, though those are weaker than for the other bases anyway (2nd base changes are never synonymous). For now I've changed the table to the third option as the first option uses horizontal lines inconsistently (eg look at the lines between leucines), but I wouldn't object to coloring of the codons if someone wants to implement it. Maybe one day someone will present the table as a 4x4x4 Borg cube that shows all trends equally :-) Adrian J. Hunter^{(talk•contribs)} 11:59, 19 September 2010 (UTC)[reply]

Just so you have something to look forward to, that was added to the article a while ago and looks great! We also have developed time-travel. DMacks (talk) 12:25, 19 September 3010 (UTC)[reply]

Would be cool if there were a VR or at least user-rotatable-3D format supported. DMacks (talk) 12:25, 19 September 2010 (UTC)[reply]

^A The codon ATG both codes for methionine and serves as an initiation site: the first ATG in the coding region is where translation into protein begins.^[1]