User:Anon490/sandbox

This is a user sandbox of Anon490. You can use it for testing or practicing edits.
This is not the sandbox where you should draft your assigned article for a dashboard.wikiedu.org course.
To find the right sandbox for your assignment, visit your Dashboard course page and follow the Sandbox Draft link for your assigned article in the My Articles section.

Get Help

Intracrine refers to a

isoforms

also act inside the cell through different mechanisms. These peptide/protein hormones, which have intracellular functions, are also called intracrines. The term 'intracrine' is thought to have been coined to represent peptide/protein hormones that also have intracellular actions. To better understand Intracrine, we can compare to Paracrine, Autocrine and endocrine. Autocrine system deal with the autocrine receptors of a cell allowing for the hormones to bind, which have been secreted from that same cell. Paracrine system is one where nearby cells get hormones from a cell, and change the functioning of those nearby cells. Endocrine system refers to when the hormones from a cell affect another cell that is very distant from the one that released the hormone.

The biological effects produced by intracellular actions are referred as intracrine effects, whereas those produced by binding to cell surface receptors are called endocrine,

paracrine

effects, depending on the origin of the hormone. The intracrine effect of some of the peptide/protein hormones are similar to their endocrine, autocrine, or paracrine effects; however, these effects are different for some other hormones.

Intracrine can also refer to a hormone acting within the cell that synthesizes it.^[1]

Examples of intracrine peptide hormones: There are several protein/peptide hormones that are also intracrines. Notable examples that have been described in the references include:

• Peptides of the

angiotensin II and angiotensin (1-7)

• Fibroblast Growth Factor -2

• Parathyroid hormone-related protein