Abafungin

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Abafungin
cream)
ATC code
  • none
Identifiers
  • N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine
JSmol)
  • CC1=CC(=C(C=C1)OC2=CC=CC=C2C3=CSC(=N3)NC4=NCCCN4)C
  • InChI=1S/C21H22N4OS/c1-14-8-9-18(15(2)12-14)26-19-7-4-3-6-16(19)17-13-27-21(24-17)25-20-22-10-5-11-23-20/h3-4,6-9,12-13H,5,10-11H2,1-2H3,(H2,22,23,24,25) checkY
  • Key:TYBHXIFFPVFXQW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Abafungin (

dermatomycoses
.

Abasol is a topical cream formulation of abafungin by York Pharma.[1]

History

Abafungin was first synthesized at

H2-antagonists related to famotidine, resulted in the discovery of its antifungal properties.[2]

Its development seems to have been discontinued in 2009.[3]

Mechanism of action

Unlike imidazole- and triazole-class antifungals, abafungin directly impairs the fungal cell membrane.[2]

In addition, abafungin inhibits the enzyme sterol 24-C-methyltransferase, modifying the composition of the fungal membrane.[4]

Abafungin has antibiotic activity against gram-positive bacteria as well as sporicidal activity.[5]

References

  1. ^ "Regulatory Update – Abasol" (PDF). York Pharma. Archived from the original (PDF) on September 27, 2007.
  2. ^
    PMID 18587237
    .
  3. ^ "Abafungin". AdisInsight. Retrieved 5 May 2021.
  4. PMID 8587237
    .
  5. ^ Ginter-Hanselmayer G (March 2009). Arbeitsunterlagen zur 42. wissenschaftlichen Fortbildungsveranstaltung für Apothekerinnen und Apotheker: Infektionskrankheiten. Österreichische Apothekerkammer. p. 103.

External links

  • Media related to Abafungin at Wikimedia Commons


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