Oxiconazole

Oxiconazole

Clinical data
Trade names	Oxistat, Oxizole
AHFS/Drugs.com	Monograph
MedlinePlus	a689004
ATC code	D01AC11 (WHO) G01AF17 (WHO)
Identifiers
IUPAC name (E)-[1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethylidene] [(2,4-dichlorophenyl)methoxy]amine
JSmol)	Interactive image
SMILES Clc3ccc(/C(=N\OCc1ccc(Cl)cc1Cl)Cn2ccnc2)c(Cl)c3
InChI InChI=1S/C18H13Cl4N3O/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22/h1-8,11H,9-10H2/b24-18- Y Key:QRJJEGAJXVEBNE-MOHJPFBDSA-N Y

Oxiconazole (trade names Oxistat in the US, Oxizole in Canada) is an

It was patented in 1975 and approved for medical use in 1983.[1]

Treatment of the ketone (1) with hydroxylamine gives the oxime (2), which is alkylated with 2,4-dichlorobenzyl chloride (3) in the presence of the strong base sodium hydride to give oxiconazole.^[2][3]

• Fluconazole