Tioconazole
 | |
| Clinical data | |
|---|---|
| Trade names | Vagistat-1, 1-Day |
| Other names | Thioconazole |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
ECHA InfoCard | 100.059.958 |
| Chemical and physical data | |
| Formula | C16H13Cl3N2OS |
| Molar mass | 387.70 g·mol−1 |
| Chirality | Racemic mixture |
  (what is this?) (verify) | |
Tioconazole is an
yeast infections.[1]
They are available in one day doses, as opposed to the 7-day treatments commonly used in the past.
Tioconazole topical (skin) preparations are also available for
jock itch, athlete's foot, and tinea versicolor
or "sun fungus".
It was patented in 1975 and approved for medical use in 1982.[2]
Side effects
Side effects of vaginal tioconazole may include temporary burning itching, or irritation of the vagina. Vaginal swelling or redness, difficulty or burning during urination, headache, abdominal pain, and upper respiratory tract infection have been reported by people using tioconazole.[3] These side effects may be only temporary, and do not normally interfere with the patient's comfort enough to outweigh the result.[citation needed]
Synthesis
Antimycotic
imidazole derivative.
A displacement reaction between 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and 2-chloro-3-(chloromethyl)thiophene is performed.
References
- ^ Tioconazole, Mayo Clinic
- ISBN 9783527607495.
- ^ "VAGISTAT-1 Print Label" (PDF). Food and Drug Administration. 6 February 1997. Retrieved 25 January 2021.
- ^ BE 841309, Gymer GE, issued 1976, assigned to Pfizer
- ^ US 4062966, Gymer GE, issued 1977, assigned to Pfizer
Wikimedia Commons has media related to Tioconazole.