Acid—CoA ligase (GDP-forming)

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Acid—CoA ligase (GDP-forming)
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ExPASy
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KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
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In

enzymology, an acid—CoA ligase (GDP-forming) (EC 6.2.1.10) is an enzyme that catalyzes the chemical reaction

GTP + an acid + CoA GDP + phosphate + acyl-CoA

The 3

substrates of this enzyme are GTP, acid, and CoA, whereas its 3 products are GDP, phosphate, and acyl-CoA
.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is acid:CoA ligase (GDP-forming). Other names in common use include acyl-CoA synthetase (GDP-forming), and acyl coenzyme A synthetase (guanosine diphosphate forming).

References

  • Rossi CR, Gibson DM (June 1964). "Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria" (PDF). The Journal of Biological Chemistry. 239 (6): 1694–9.
    PMID 14213337
    .