Circovirus
Circovirus | |
---|---|
Virus classification | |
(unranked): | Virus |
Realm: | Monodnaviria |
Kingdom: | Shotokuvirae |
Phylum: | Cressdnaviricota |
Class: | Arfiviricetes |
Order: | Cirlivirales |
Family: | Circoviridae |
Genus: | Circovirus |
Circovirus is a genus of
Taxonomy
The following species are recognized:
- Barbel circovirus
- Bat associated circovirus 1
- Bat associated circovirus 2
- Bat associated circovirus 3
- Bat associated circovirus 4
- Bat associated circovirus 5
- Bat associated circovirus 6
- Bat associated circovirus 7
- Bat associated circovirus 8
- Bat associated circovirus 9
- Bat associated circovirus 10
- Bat associated circovirus 11
- Bat associated circovirus 12
- Bat associated circovirus 13
- Beak and feather disease virus
- Bear circovirus
- Canary circovirus
- Canine circovirus
- Chimpanzee associated circovirus 1
- Civet circovirus
- Duck circovirus
- Elk circovirus
- European catfish circovirus
- Finch circovirus
- Goose circovirus
- Gull circovirus
- Human associated circovirus 1 (HCirV-1)
- Mink circovirus
- Mosquito associated circovirus 1
- Penguin circovirus
- Pigeon circovirus
- Porcine circovirus 1
- Porcine circovirus 2
- Porcine circovirus 3
- Porcine circovirus 4
- Raven circovirus
- Rodent associated circovirus 1
- Rodent associated circovirus 2
- Rodent associated circovirus 3
- Rodent associated circovirus 4
- Rodent associated circovirus 5
- Rodent associated circovirus 6
- Rodent associated circovirus 7
- Starling circovirus
- Swan circovirus
- Tick associated circovirus 1
- Tick associated circovirus 2
- Whale circovirus
- Zebra finch circovirus
Structure
Viruses in Circovirus are non-enveloped, with icosahedral and round[clarification needed] geometries, and T=1 symmetry.[7] The diameter is around 17 nm. Genomes are circular and non-segmented.[5]
The virions of Circoviruses are surprisingly small, with diameters ranging from 17 up to 22 nm.[8]
Genus | Structure | Symmetry | Capsid | Genomic arrangement | Genomic segmentation |
---|---|---|---|---|---|
Circovirus | Icosahedral | T=1 | Non-enveloped | Circular | Monopartite |
Life cycle
Viral replication is nuclear. Entry into the host cell is achieved by penetration. Replication follows the ssDNA rolling circle model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and nuclear pore export. Birds and pigs serve as the natural host.[9][7] The virus is known to cause "immunosuppressive conditions" in animals that are infected; as well as having the ability to jump between species, creating difficulty in identifying the origin of infection.[7][10][11][12][13][14] Transmission routes are fecal-oral and parental.[5]
Genus | Host details | Tissue tropism | Entry details | Release details | Replication site | Assembly site | Transmission |
---|---|---|---|---|---|---|---|
Circovirus | Birds; pigs | None | Cell receptor endocytosis | Budding | Nucleus | Nucleus | Horizontal; oral-fecal |
Genome
Circovirus has a monopartite, circular, and ssDNA genome of between 1759 and 2319nt, making it possibly the virus of shortest genome size in mammal viruses. The virus replicates through an dsDNA intermediate initiated by the Rep protein. Two major genes are transcribed from open reading frame (ORF) 1 and 2. ORF1 encodes Rep and Rep' for initiation of rolling-circle replication; ORF2 encodes Cap, the only structural and most immunogenic protein forming the viral capsid.[15]
References
- PMID 16772130.
- PMID 22684469.
- PMID 22027190.
- ^ Vogelsang J (September 14, 2013). "5 Things You Need to Know About the 'Circovirus Outbreak'". Yahoo News.
- ^ a b c "Circovirus". Viral Zone. ExPASy. Retrieved 15 June 2015.
- ^ "Circovirus Family: Circoviridae". Virus Taxonomy: 2020 Release. International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 11 May 2021.
- ^ PMID 38176604.
- ^ Barich D (ed.). "Circovirus". MicrobeWiki. Department of Biology, Kenyon College.
- S2CID 219398908.
- PMID 20460225.
- PMID 23141170.
- PMID 23892461.
- S2CID 254052514.
- PMID 36894948.
- ISBN 978-0-12-374410-4. Retrieved 2023-10-04.