Birnaviridae

Source: Wikipedia, the free encyclopedia.

Birnaviridae
Infectious bursal disease virus
particle
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: incertae sedis
Family: Birnaviridae

Birnaviridae is a family of double-stranded RNA viruses.[1] Salmonid fish, birds and insects serve as natural hosts. There are currently 11 species in this family, divided among seven genera.[2] Diseases associated with this family include infectious pancreatic necrosis in salmonid fish, which causes significant losses to the aquaculture industry, with chronic infection in adult salmonid fish and acute viral disease in young salmonid fish.[2][3]

Structure

Viruses in family Birnaviridae are non-enveloped, with icosahedral single-shelled geometries, and T=13 symmetry. The diameter is around 70 nm.[2][3]

Genome

Genome of infectious bursal disease virus of family Birnaviridae

The genome is composed of linear, bi-segmented, double-stranded RNA. It is around 5.9–6.9 kbp in length and codes for five to six proteins. Birnaviruses encode the following proteins:

highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RNA-directed RNA polymerases.[4]

The large RNA segment, segment A, of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [5] that is processed into the major structural proteins of the virion: VP2, VP3 (a minor structural component of the virus), and into the putative protease VP4.[5] VP4 protein is involved in generating VP2 and VP3.[5] recombinant VP3 is more immunogenic than recombinant VP2.[6]

epitopes. The variable domain of VP2 and the 20 adjacent amino acids of the conserved C-terminal are probably the most important in inducing an immune response for the protection of animals.[7]

Non

structural protein VP5 is found in RNA segment A.[citation needed] The function of this small viral protein is unknown. It is believed to be involved in influencing apoptosis, but studies are not completely concurring. The protein can not be found in the virion.[citation needed
]

Viral Replication

Viral replication is cytoplasmic. Entry into the host cell is achieved by cell receptor endocytosis. Replication follows the double-stranded RNA virus replication model in the cytoplasm. Double-stranded RNA virus transcription is the method of transcription in cytoplasm. The virus is released by budding. Salmonid fish (Aquabirnavirus), young sexually immature chickens (Avibirnavirus), insects (Entomobirnavirus), and blotched snakehead fish (Blosnavirus) as the natural host. Transmission routes are contact.[2][3]

Taxonomy

Phylogenetic tree of Birnaviridae

The following genera are recognized:

References

  1. PMID 30484762
    .
  2. ^ a b c d "Birnaviridae—Birnaviridae—dsRNA Viruses". International Committee on Taxonomy of Viruses (ICTV). Retrieved 16 October 2019.[dead link]
  3. ^ a b c "Viral Zone". ExPASy. Retrieved 12 June 2015.
  4. PMID 12069523
    .
  5. ^
    PMID 2828658
    .
  6. S2CID 22958612
    .
  7. ^
    PMID 8525637
    .
  8. PMID 17976679
    .

External links