Fazio–Londe disease
Fazio–Londe disease | |
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Other names | Progressive bulbar palsy of childhood |
This condition has an autosomal recessive mode of inheritance | |
Specialty | Neurology |
Fazio–Londe disease (FLD), also called progressive bulbar palsy of childhood,
Signs and symptoms
FLD produces rapidly progressive weakness of tongue, face and
Genetics
Fazio–Londe disease is linked to a genetic
Diagnosis
Symptoms of Fazio–Londe include bulbar palsy, hearing loss, facial weakness, and difficulty breathing. The disease is caused by mutations in the SLC52A2 gene and the SLC52A1 (GPR172B) genes which code for hRFT3 and hRFT1, human riboflavin transporters. Only muscle biopsy and examination of the transporter genes is considered to provide a definitive diagnosis. However, because the disease is so often fatal without treatment, and because the treatment is so inexpensive and with little risk, it is recommended that if the disease is suspected that riboflavin therapy be started immediately while testing is in progress.[7]
Treatment
The condition is treatable.[8] High doses of oral riboflavin 5 phosphate may work,[7] and sublingual FAD[expand acronym] may work.[citation needed]
Prognosis
Onset of first symptom has been reported between 1–12 years, with a mean age of onset at 8 years. Clinical course can be divided into early (< 6 yrs age, predominance of respiratory symptoms) and late course (6–20 years of age, predominance of motor symptoms on superior limbs). Progression to involve other cranial nerve muscles occurs over a period of months or years. In the Gomez review facial nerve was affected in all cases while hypoglossal nerve was involved in all except one case. Other cranial nerves involved were vagus, trigeminal, spinal accessory nerve, abducens, oculomotor and glossopharyngeal in this order. Corticospinal tract signs were found in 2 of the 14 patients.[citation needed]
The disease may progress to patient's death in a period as short as 9 months or may have a slow evolution or may show plateaus. Postmortem examination of cases have found depletion of nerve cells in the nuclei of cranial nerves. The histologic alterations found in patient with Fazio–Londe disease were identical to those seen in infantile-onset spinal muscular atrophy.[citation needed]
Strength may improve with administration of cholinesterase inhibitors.[citation needed]
History
Berger, in 1876, first reported a case of 12-year-old child with progressive bulbar paralysis. History revealed a neurological illness with difficulty in swallowing liquids and solids, nasal regurgitation to liquids, nasal twang 2 years ago. He was treated as post-diptheritic bulbar palsy and had a residual bulbar weakness. Other details were not available. Child was ambulant and was apparently normal until 3 months back when he developed respiratory distress and was treated at a local hospital prior to referral. He had a past history of dog bite 3 months ago for which he received five doses of ARV. He was born out of a non-consanguineous marriage. The antenatal, natal, postnatal histories were insignificant. His elder sibling was healthy. This child was immunised appropriate for age. There was no family history of any neurological illness or sibling death.[9]
Eponym
It is named for the Italian pathologist Eugenio Fazio (1849–1902) and the French physician Paul Frederic Louis Londe (1864–1944).[10][11]
References
- ^ a b c d Online Mendelian Inheritance in Man (OMIM): 211500
- PMID 1486466.
- ISBN 978-1455748129. Retrieved 5 December 2017.
- ^ "OMIM Entry - # 211500 - FAZIO-LONDE DISEASE". www.omim.org. Retrieved 18 July 2021.
- ^ "Fazio-Londe Disease - Tests - GTR - NCBI". www.ncbi.nlm.nih.gov. Retrieved 18 July 2021.
- S2CID 32223440.
- ^ PMID 23107375.
- PMID 25745320.
- ^ Poovazhagi Varadarajan, Vimal Thayanathi, and Leema C. Pauline. (2015). Fazio Londe syndrome: A treatable disorder. Ann Indian Acad Neurol, 18(1), 87-89
- Who Named It?
- ^ Londe, P. Paralysie bulbaire progressive, infantile et familiale. Rev. Med. 14: 212–254, 1894.