FCER1
(Redirected from
FcεRI
)
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| High affinity IgE receptor; gamma | |||||||
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| Identifiers | |||||||
| Symbol | FCER1G | ||||||
| Alt. symbols | FcεRIγ | ||||||
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The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-
FcεRIβ – which amplifies the downstream signal), and two gamma chains (FcεRIγ – the site where the downstream signal initiates) connected by two disulfide bridges on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils[2] and is inducible in eosinophils
.
Tissue distribution
FcεRI is found on epidermal Langerhans cells, eosinophils, mast cells, and basophils.[3][4][5] As a result of its cellular distribution, this receptor plays a major role in controlling allergic responses. FcεRI is also expressed on antigen-presenting cells, and controls the production of important immune mediators (cytokines, interleukins, leukotrienes, and prostaglandins) that promote inflammation.[6] The most known mediator is histamine, which results in the five symptoms of inflammation: heat, swelling, pain, redness and loss of function.
FcεRI was demonstrated in bronchial/tracheal airway
Mechanism of action
Crosslinking of the FcεRI via IgE-
autoantibodies to the FcεRIα have been isolated from human cord blood, which suggest that they occur naturally and are present already at birth. However, their epitope on FcεRIα was masked by IgE, and the affinity of the corresponding autoantibodies found in healthy adults appeared lowered.[10]
See also
References
External links
- Fc+epsilon+RI at the U.S. National Library of Medicine Medical Subject Headings (MeSH)