Fibrosarcoma

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Fibrosarcoma
Micrograph of a tumour with the herringbone pattern as may be seen in fibrosarcoma. H&E stain.
SpecialtyOncology Edit this on Wikidata

Fibrosarcoma (fibroblastic sarcoma) is a

anaplastic spindle cells in a storiform pattern. Fibrosarcomas mainly arise in people between the ages of 25 and 79.[1]
It originates in fibrous tissues of the bone and invades long or flat bones such as the femur, tibia, and mandible. It also involves the periosteum and overlying muscle.

Presentation

Adult-type

Individuals presenting with fibrosarcoma are usually adults thirty to fifty-five years old, often presenting with pain. Among adults, fibrosarcomas develop equally in men and women. [2]

Infantile-type

In infants, fibrosarcoma (often termed congenital infantile fibrosarcoma) is usually congenital. Infants presenting with this fibrosarcoma usually do so in the first two years of their life. Cytogenetically, congenital infantile fibrosarcoma is characterized by the majority of cases having a

Beta-catenin) within this tumor are similar to those found in the cellular form of mesoblastic nephroma. Indeed, mesoblastic nephroma and congenital infantile sarcoma appear to be the same disease with the exception that mesoblastic lymphoma originates in the kidney whereas congenital infantile sarcoma originates in non-renal tissues.[4][5][6]

Pathology

The tumor may present different degrees of

biphenotypic sinonasal sarcoma.[citation needed
]

Diagnosis

Ancillary testing for fibrosarcoma includes

S100 are negative, and actin is variable.[citation needed
]

In animals

Cat after fourth fibrosarcoma operation

Dogs

Fibrosarcoma occurs most frequently in the mouth in dogs.[7] The tumor is locally invasive, and often recurs following surgery.[8] Radiation therapy and chemotherapy are also used in treatment. Fibrosarcoma is also a rare bone tumor in dogs.[9]

Cats

In cats, fibrosarcoma occurs on the skin. It is also the most common

Merial launched Oncept IL-2 in Europe for the management of such feline fibrosarcomas.[10]

Bostock DE, et al. performed a study of cats that had fibrosarcomas excised and were followed for a minimum of three years, or until death. Two factors, tumor site and mitotic index, were found to be of prognostic significance, but tumor size, duration of growth, and histologic appearance were not. Following removal of fibrosarcomas from the flank in six cats, none died as a result of the tumor but 24 of 35 (70%) cats with fibrosarcoma in the skin of the head, back, or limbs were euthanized because of local recurrence, usually within nine months of surgery.[11]

See also

References

  1. ^ "fibrosarcoma". encyclopedia.com. Retrieved 2021-10-30.
  2. ^ "Fibrosarcoma". encyclopedia.com. Retrieved 2021-10-30.
  3. PMID 23938179
    .
  4. PMID 27020209
    .
  5. PMID 25295083
    .
  6. S2CID 25198570
    .
  7. ^ "Oral Tumors in Dogs - Fibrosarcomas". vca_corporate. Retrieved 2019-05-29.
  8. ^ Fossum, Theresa Welch (2013). Small Animal Surgery Textbook. Elsevier Health Sciences. p. 414.
  9. ^
    ISBN 0-7216-6795-3
    .
  10. ^ "Merial Launches Oncept IL-2, The First Veterinary Immunotherapeutic Product In Europe For The Management Of Cancer In Pets". www.vetclick.com/. February 23, 2016. Retrieved February 23, 2016.
  11. PMID 528318
    .

External links
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