Florfenicol

Source: Wikipedia, the free encyclopedia.
Florfenicol
QJ51BA90 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • Veterinary use only
Identifiers
  • 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
JSmol)
  • ClC(Cl)C(=O)N[C@@H]([C@H](O)c1ccc(cc1)S(=O)(=O)C)CF
  • InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1 checkY
  • Key:AYIRNRDRBQJXIF-NXEZZACHSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Florfenicol (marketed by Schering-Plough Animal Health under the trade name Nuflor) is a fluorinated synthetic analog of thiamphenicol,[1] mainly used as a antibiotic in veterinary medicine.

As a generic, it is now available worldwide.[2]

Indications

In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Prevotella melaninogenica.

In swine, it is indicated for the treatment of respiratory infections caused by Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Glaesserella parasuis, P. multocida, and Streptococcus suis.

Florfenicol is also used in aquaculture, and is licensed for use in the United States for the control of enteric septicemia in catfish.[3]

Since the early 2000s, it has been used in

laying hens, due to residues in eggs. It is also indicated in turkey
.

The use of florfenicol in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available.[6]

Contamination

Florfenicol was among the drug contaminants in a brand of supermarket eggs in Taiwan and Iran.[7]

External links

References

  1. PMID 6957162
    .
  2. ^ "Florfenicol". Drugs.com.
  3. PMID 22882087
    .
  4. ^ "Florfenicol (Extension to Chicken)" (PDF). Committee for Veterinary Medicinal Products. European Medicines Agency. March 1999. Archived from the original (PDF) on 2018-09-20. Retrieved 2016-05-10.
  5. PMID 12204631
    .
  6. ISBN 978-1-4160-5475-7
    . Retrieved March 21, 2011.
  7. ^ I-chia L (8 January 2013). "Survey suggests certain eggs may be dangerous". Taipei Times. Retrieved 3 November 2014.
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