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Chemical compound
Troleandomycin AHFS /Drugs.com Multum Consumer Information MedlinePlus a604026 ATC code
(3R ,5R ,6R ,7S ,8R ,11R ,12S ,13R ,14S ,15S )-12-[(4-O -acetyl-2,6-dideoxy-3-O -methyl-α-L -arabino -hexopyranosyl)oxy]-14-{[2-O -acetyl-3,4,6-trideoxy-3-(dimethylamino)-β-D -xylo -hexopyranosyl]oxy}-5,7,8,11,13,15-hexamethyl-4,10-dioxo-1,9-dioxaspiro[2.13]hexadec-6-yl acetate
JSmol)
InChI=1S/C41H67NO15/c1-19-17-41(18-49-41)38(46)23(5)34(53-27(9)43)21(3)25(7)52-39(47)24(6)35(56-32-16-31(48-14)36(26(8)51-32)54-28(10)44)22(4)33(19)57-40-37(55-29(11)45)30(42(12)13)15-20(2)50-40/h19-26,30-37,40H,15-18H2,1-14H3/t19-,20+,21-,22+,23+,24+,25+,26-,30-,31-,32-,33-,34-,35-,36-,37+,40-,41-/m0/s1
Y Key:LQCLVBQBTUVCEQ-MCQAQMIOSA-N
Y
N Y (what is this?) (verify)
Troleandomycin (TAO for short[1] ) is a macrolide antibiotic. It was sold in Italy (branded Triocetin ) and Turkey (branded Tekmisin ). It is no longer sold in Italy as of 2018.[citation needed ]
The drug's mode of action is to bind to the ribosome, specifically in the tunnel through which the newly formed peptide egresses, thereby halting protein synthesis.[2]
Troleandomycin is a CYP3A4 inhibitor that may cause drug interactions .[citation needed ]
References