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Other namesGoiter
Diffuse hyperplasia of the thyroid

A goitre, or goiter, is a swelling in the neck resulting from an enlarged thyroid gland.[1][2] A goitre can be associated with a thyroid that is not functioning properly.

Worldwide, over 90% of goitre cases are caused by iodine deficiency.[3] The term is from the Latin gutturia, meaning throat. Most goitres are not cancerous (benign), though they may be potentially harmful.

Signs and symptoms

A goitre can present as a palpable or visible enlargement of the

non-specific and make diagnosis difficult.[citation needed

According to the WHO classification of goitre by palpation, the severity of goitre is currently graded as grade 0, grade 1, grade 2.[5]

  • Goitre Class II, WHO grade 2
    Goitre Class II, WHO grade 2
  • Goitre Class III, WHO grade 2
    Goitre Class III, WHO grade 2


Worldwide, the most common cause for goitre is

iodized salt. Selenium deficiency is also considered a contributing factor. In countries that use iodized salt, Hashimoto's thyroiditis is the most common cause.[6] Goitre can also result from cyanide poisoning, which is particularly common in tropical countries where people eat the cyanide-rich cassava root as the staple food.[7]

Cause Pathophysiology Resultant thyroid activity Growth pattern Treatment Incidence and prevalence Prognosis
Iodine deficiency Hyperplasia of thyroid to compensate for decreased efficacy Can cause hypothyroidism Diffuse Iodine Constitutes over 90% cases of goitre worldwide[3] Increased size of thyroid may be permanent if untreated for around five years
Congenital hypothyroidism Inborn errors of thyroid hormone synthesis Hypothyroidism
Goitrogen ingestion
Adverse drug reactions
Hashimoto's thyroiditis Autoimmune disease in which the thyroid gland is gradually destroyed. Infiltration of lymphocytes. Hypothyroidism Diffuse and
Thyroid hormone replacement
Prevalence: 1 to 1.5 in a 1000 Remission with treatment
Pituitary disease Hypersecretion of
thyroid stimulating hormone, almost always by a pituitary adenoma[9]
Diffuse Pituitary surgery Very rare[9]
Graves' disease—also called Basedow syndrome
Autoantibodies (TSHR-Ab) that activate the TSH
-receptor (TSHR)
Hyperthyroidism Diffuse Antithyroid agents, radioiodine, surgery Will develop in about 0.5% of males and 3% of females Remission with treatment, but still lower quality of life for 14 to 21 years after treatment, with lower mood and lower vitality, regardless of the choice of treatment[10]
Thyroiditis Acute or chronic inflammation Can be hyperthyroidism initially, but progress to hypothyroidism
Thyroid cancer Usually uninodular Overall relative
5-year survival rate of 85% for females and 74% for males[11]
Benign thyroid neoplasms Usually hyperthyroidism Usually uninodular Mostly harmless[12]
Thyroid hormone insensitivity
Secretional hyperthyroidism,
Symptomatic hypothyroidism


Goitre with toxic adenoma

Goitre may be diagnosed via a

thyroid function test in an individual suspected of having it.[13]


A goitre may be classified either as nodular or diffuse. Nodular goitres are either of one nodule (uninodular) or of multiple nodules (multinodular).[14] Multinodular goiter (MNG) is the most common disorder of the thyroid gland.[15]

Growth pattern
  • Uninodular goitre: one thyroid nodule; can be either inactive, or active (toxic) – autonomously producing thyroid hormone.
  • Multinodular goitre: multiple nodules;[16] can likewise be inactive or toxic, the latter is called toxic multinodular goitre and associated with hyperthyroidism. These nodules grow up at varying rates and secrete thyroid hormone autonomously, thereby suppressing TSH-dependent growth and function in the rest of gland. Inactive nodules in the same goitre can be malignant.[17] Thyroid cancer is identified in 13.7% of the patients operated for multinodular goitre.[18]
  • Diffuse goitre: the whole thyroid appearing to be enlarged due to hyperplasia.
  • Class I: the goitre in normal posture of the head cannot be seen; it is only found by palpation.
  • Class II: the goitre is palpable and can be easily seen.
  • Class III: the goitre is very large and is retrosternal (partially or totally lying below the sternum), pressure results in compression marks.


Goitre is treated according to the cause. If the

KI solution are given. If the goitre is associated with an underactive thyroid, thyroid supplements are used as treatment. Sometimes a partial or complete thyroidectomy is required.[19]


Disability-adjusted life year for iodine deficiency per 100,000 inhabitants in 2002.[20]
  no data
  fewer than 50
  more than 800

Goitre is more common among women, but this includes the many types of goitre caused by autoimmune problems, and not only those caused by simple lack of iodine.[21]

Iodine mainly accumulates in the sea and in the topsoil. Before iodine enrichment programs, goiters was common in areas with repeated flooding or glacial activities, which erodes the topsoil. It is endemic in populations where the intake of iodine is less than 10 μg per day.[22]

Examples of such regions include the alpine regions of Southern Europe (such as Switzerland), the Himalayans, the Great Lakes basin, etc. As reported in 1923, all the domestic animals have goiter in some of the glacial valleys of Southern Alaska. It was so severe in Pemberton Meadows that it was difficult to raise young animals there.[23]


Goitre and congenital iodine deficiency syndrome in Styria, copper engraving, 1815
Woman in Miesbacher Tracht wearing a goitre choker

Chinese physicians of the Tang dynasty (618–907) were the first to successfully treat patients with goitre by using the iodine-rich thyroid gland of animals such as sheep and pigs—in raw, pill, or powdered form.[24] This was outlined in Zhen Quan's (d. 643 AD) book, as well as several others.[24] One Chinese book, The Pharmacopoeia of the Heavenly Husbandman, asserted that iodine-rich sargassum was used to treat goitre patients by the 1st century BC, but this book was written much later.[24]

In the 12th century,

Persian physician, provided the first description of Graves' disease after noting the association of goitre and a displacement of the eye known as exophthalmos in his Thesaurus of the Shah of Khwarazm, the major medical dictionary of its time.[25][26] The disease was later named after Irish doctor Robert James Graves, who described a case of goitre with exophthalmos in 1835. The German Karl Adolph von Basedow also independently reported the same constellation of symptoms in 1840, while earlier reports of the disease were also published by the Italians Giuseppe Flajani and Antonio Giuseppe Testa, in 1802 and 1810 respectively,[27] and by the English physician Caleb Hillier Parry (a friend of Edward Jenner) in the late 18th century.[28]

Paracelsus (1493–1541) was the first person to propose a relationship between goitre and minerals (particularly lead) in drinking water.[29] Iodine was later discovered by Bernard Courtois in 1811 from seaweed ash.[30]

Goitre was previously common in many areas that were deficient in iodine in the

supplemented with iodine. However, it is still prevalent in India, China,[33] Central Asia, and Central Africa

Goitre had been prevalent in the alpine countries for a long time. Switzerland reduced the condition by introducing

Salzburg regions, which appeared in the 19th century, includes a choker, dubbed Kropfband (struma band) which was used to hide either the goitre or the remnants of goitre surgery.[34]

Society and culture

In the 1920s wearing bottles of iodine around the neck was believed to prevent goitre.[35]

Notable cases

  • Former U.S. President
    cardiac dysrhythmia.[36][37] Scientists said that, absent an environmental cause, the odds of both a husband and wife having Graves' disease might be 1 in 100,000 or as low as 1 in 3,000,000.[38]


The coat of arms and crest of Die Kröpfner, of

Tyrol showed a man "afflicted with a large goitre", an apparent pun on the German for the word ("Kropf").[39]

See also


  1. ^ "Thyroid Nodules and Swellings". British Thyroid Foundation. 11 September 2019.
  2. ^ "Goitre - NHS Choices". NHS Choices. 19 October 2017.
  3. ^
    ISBN 3-936072-27-2.{{cite book}}: CS1 maint: location missing publisher (link
  4. ^ Porth CM, Gaspard KJ, Noble KA (2011). Essentials of pathophysiology: Concepts of altered health states (3rd ed.). Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins.
  5. ^ "Goitre as a determinant of the prevalence and severity of iodine deficiency disorders in populations". World Health Organization. 2014.
  6. .
  7. ^ "Toxicological Profile For Cyanide" (PDF). Atsdr.cdc.gov. Archived (PDF) from the original on 28 July 2004. Retrieved 16 March 2017.
  8. PMID 21119426
  9. ^ a b Thyrotropin (TSH)-secreting pituitary adenomas. By Roy E Weiss and Samuel Refetoff. Last literature review version 19.1: January 2011. This topic last updated: July 2, 2009
  10. PMID 16356093
  11. .
  12. .
  13. ^ "Goitre". nhs.uk. 19 October 2017. Retrieved 27 March 2019.
  14. ^ "Nodular Goiter - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 6 March 2022.
  15. PMID 25905424
  16. .
  17. ^ "Toxic multinodular goitre - Symptoms, diagnosis and treatment | BMJ Best Practice". bestpractice.bmj.com.
  18. PMID 15481700
  19. ^ "Goiter – Simple". The New York Times.
  20. ^ "Mortality and Burden of Disease Estimates for WHO Member States in 2002" (xls). World Health Organization. 2002.
  21. ^ 1
  22. ^ Goitre as a determinant of the prevalence and severity of iodine deficiency disorders in populations, World Health Organization - 2014
  23. PMID 18010882
  24. ^ .
  25. Who Named It?
    – the history and naming of the disease
  26. .
  27. Who Named It?
  28. .
  29. ^ "Paracelsus" Britannica
  30. S2CID 109845199
  31. ^ "Iodine Deficiency". Archived from the original on 18 November 2022. Retrieved 27 February 2021.
  32. PMID 888801
  33. ^ "In Raising the World's I.Q., the Secret's in the Salt", article by Donald G. McNeil, Jr., December 16, 2006, The New York Times
  34. ^ Wissen, Planet (16 March 2017). "Planet Wissen".
  35. ^ "ARCHIVED – Why take iodine?". Nrc-cnrc.gc.ca. 30 September 2011. Retrieved 1 November 2012.
  36. .
  37. ^ Altman LK (14 September 1991). "A White House Puzzle: Immunity Ailments". The New York Times. Doctors Say Bush Is in Good Health
  38. ^ Altman LK (28 May 1991). "The Doctor's World; A White House Puzzle: Immunity Ailments". The New York Times.
  39. ^ Fox-Davies AC (1904). The Art of Heraldry: An Encyclopædia of Armory. New York and London: Benjamin Blom, Inc. p. 413.

External links

  • The dictionary definition of goitre at Wiktionary
  • Media related to Goiters at Wikimedia Commons
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