mir-103/107 microRNA precursor
| mir-103/107 microRNA precursor | |
|---|---|
| SO | SO:0001244 |
| PDB structures | PDBe |
The miR-103 microRNA precursor (
gene regulation
.
miR-103 and miR-107 have now been predicted or experimentally confirmed in
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to
mRNA.[3]
mir-103 and mir-107 were noted as being upregulated in
insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.[4]
mir-103 has also been linked with
intestinal cell proliferation.[6]
Recently, miR-103-3p was shown to target the 5'
miRNA
targets the 5' UTR of a mRNA.
References
- PMID 11914277.
- ^ "miRNA gene family: mir-103". mirBASE. University of Manchester. Archived from the original on 10 July 2012. Retrieved 5 September 2011.
- PMID 11779458.
- S2CID 2060531.
- PMID 21804529.
- PMID 20886090.
- PMID 24984703.
External links