mir-17 microRNA precursor family
| mir-17 microRNA precursor family | |
|---|---|
| SO | SO:0001244 |
| PDB structures | PDBe |
The miR-17 microRNA precursor family are a group of related small
The
paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs.[4] The oncogenic potential of these non-protein encoding genes was first identified in mouse viral tumorigenesis screens.[5][6][7]
In humans, the activating mutations of miR-17~92 have been identified in non-Hodgkin's lymphoma, whereas the miRNA constituents of the clusters are overexpressed in a multiple cancer types.[8][9][10] High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects.[11] In addition, in the nasopharyngeal carcinoma cell line, miR-20a and miR-20b has been shown to target the 3’ UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor.[12][13] miR-20a detection in human faeces could be a non-invasive screening marker for colorectal cancer.[14]
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- PMID 20940405.
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- PMID 20878079.
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- PMID 20656682.
- PMID 20538815.
- S2CID 24272629.
- PMID 20504959.
- PMID 20437201.
- PMID 20406979.
- PMID 20305691.
- S2CID 31290845.
- PMID 20227518.
- PMID 20215348.
- S2CID 4579895.
- PMID 20167088.
- S2CID 205786377.
- PMID 20133587.
- PMID 20089119.
- PMID 20047995.
- PMID 20022054.
- PMID 20008935.
- PMID 20008931.
- PMID 19956752.
- S2CID 37278212.
- S2CID 21807969.
- PMID 19696742.
- PMID 19672269.
- PMID 19666108.
- S2CID 5180603.
- S2CID 1939787.
- PMID 19559694.
- PMID 19351822.
- PMID 19287466.
- PMID 19196975.
- S2CID 40256612.
- PMID 19073166.
- PMID 19066217.
- PMID 18922889.
- PMID 18836483.
- PMID 18700987.
- PMID 18688024.
- S2CID 5288582.
- PMID 18632605.
- PMID 18429962.
- PMID 18423194.
- PMID 18329372.
- PMID 18327259.
- PMID 18287052.
- PMID 17956675.
- PMID 17904311.
- PMID 17765889.
- S2CID 26390039.
- PMID 17384677.
- S2CID 2941415.
- PMID 17284533.
- PMID 17218954.
- PMID 16940181.
- PMID 16266980.
- S2CID 11081775.
- PMID 19048628.