mir-1 microRNA precursor family
| miR-1 | |
|---|---|
Chr. 20 q13.33 | |
| PDB structures | PDBe |
The miR-1 microRNA precursor is a small
mRNA
. In humans there are two distinct microRNAs that share an identical mature sequence, and these are called miR-1-1 and miR-1-2.
These micro RNAs have pivotal roles in development and physiology of muscle tissues including the heart.[2][3] MiR-1 is known to play an important role in heart diseases such as hypertrophy, myocardial infarction, and arrhythmias.[4][5][6] Studies have shown that MiR-1 is an important regulator of heart adaption after ischemia or ischaemic stress and it is upregulated in the remote myocardium of patients with myocardial infarction.[7] Also MiR-1 is downregulated in myocardial infarcted tissue compared to healthy heart tissue.[8] Plasma levels of MiR-1 can be used as a sensitive biomarker for myocardial infarction.[9]
Targets of miR-1
The heat shock protein,
HSP60 is also known to be a target for post-transcriptional regulation by miR-1 and miR-206. HSP60 is a component of the defence mechanism against diabetic myocardial injury and its level is reduced in the diabetic myocardium. In both in vivo and in vitro experiments increased levels of glucose in myocardiomyctes led to significant upregulation of miR-1 and miR-206 with resulting modulation of HSP60 leading to accelerated glucose-mediated apoptosis in cardiomyocytes.[10]
MiR-1 has key roles in the development and differentiation of smooth and skeletal muscles.Texel sheep creates a miR-1 and miR-206 target site. This is likely to cause the muscular phenotype of this breed of sheep.[15]
Clinical relevance of miR-1
Mir-1 plays an important role in some cancers. Rhabdomyosarcoma is the most common soft tissue sarcoma in children. Since the tumor results from undifferentiated cells, agents that promote differentiation hold promise as possible therapies. A study showed that levels of mir-1 and mir-133a were drastically reduced in tumourous cell lines whilst their targets were up-regulated.[16]
Introduction of miR-1 and miR-133a into an embryonal rhabdomyosarcoma-derived cell line is cytostatic, which suggested a strong tumour-suppressive role for these microRNAs. Expression of miR-1 but not miR-133a gave transcriptional profiles that were consistent with a strong promyogenic influence on the cells, again demonstrating the role of miR-1 in muscle differentiation from precursor stem cells. The authors propose that miR-1 and miR-133a act to repress isoforms of genes that are not normally expressed in muscle cells. All of these observations suggest that mis-regulation of miR-1 and miR-133a can result in tumorogenesis via abolition of the suppressive effect they have on certain gene targets and of the removal of the promotion of differentiation of the cells exerted my miR-1.[16]
The involvement of miR-1 in cancer is not limited to cancers of muscle and muscle tissues. MiR-1 may have a tumour-suppressive effect in bladder cancer by regulation of LIM and SH3 protein 1 (LASP1) .[17]
There is evidence for the role of miR-1-2 as a modulator in
EVI1, ectopic virus expression site 1. ChIP assays have shown that EVI1 binds strongly to the promoters of miR-1-2 and miR-133-a-1, and expression of EVI1 is significantly correlated with the expression of miR-1-2 and miR-133-a-1 in established cell lines and in patient samples. However, only miR-1-2 was involved in abnormal proliferation in EVI1 expressing cell lines.[18]
miR-1 and related microRNA miR-499 are proposed to be involved in the regulation of
proto-oncogene in cell lines HepG2 by targeting the 3'UTR of ets1. ets1 is involved in extracellular matrix
(ECM) degradation which is an important process required for tumor cell invasion and migration.
References
Further reading
- Xie C, Huang H, Sun X, Guo Y, Hamblin M, Ritchie RP, et al. (February 2011). "MicroRNA-1 regulates smooth muscle cell differentiation by repressing Kruppel-like factor 4". Stem Cells and Development. 20 (2): 205–10. PMID 20799856.
- Chen J, Yin H, Jiang Y, Radhakrishnan SK, Huang ZP, Li J, et al. (February 2011). "Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation". Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (2): 368–75. PMID 21051663.
- Sumiyoshi K, Kubota S, Ohgawara T, Kawata K, Nishida T, Shimo T, et al. (November 2010). "Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells". Biochemical and Biophysical Research Communications. 402 (2): 286–90. PMID 20937250.
- Li Q, Song XW, Zou J, Wang GK, Kremneva E, Li XQ, et al. (July 2010). "Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy". Journal of Cell Science. 123 (Pt 14): 2444–52. S2CID 11750031.
- Jiang Y, Yin H, Zheng XL (November 2010). "MicroRNA-1 inhibits myocardin-induced contractility of human vascular smooth muscle cells". Journal of Cellular Physiology. 225 (2): 506–11. S2CID 45605427.
- Cheng Y, Tan N, Yang J, Liu X, Cao X, He P, et al. (April 2010). "A translational study of circulating cell-free microRNA-1 in acute myocardial infarction". Clinical Science. 119 (2): 87–95. PMID 20218970.
- Sluijter JP, van Mil A, van Vliet P, Metz CH, Liu J, Doevendans PA, et al. (April 2010). "MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells". Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (4): 859–68. PMID 20081117.
- Divakaran VG (2010). "MicroRNAs miR-1, -133 and -208: same faces, new roles". Cardiology. 115 (3): 172–3. S2CID 45134661.
- Girmatsion Z, Biliczki P, Bonauer A, Wimmer-Greinecker G, Scherer M, Moritz A, et al. (December 2009). "Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation". Heart Rhythm. 6 (12): 1802–9. PMID 19959133.
- Elia L, Contu R, Quintavalle M, Varrone F, Chimenti C, Russo MA, et al. (December 2009). "Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological conditions". Circulation. 120 (23): 2377–85. PMID 19933931.
- Ai J, Zhang R, Li Y, Pu J, Lu Y, Jiao J, et al. (January 2010). "Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction". Biochemical and Biophysical Research Communications. 391 (1): 73–7. PMID 19896465.
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- Shan H, Li X, Pan Z, Zhang L, Cai B, Zhang Y, et al. (November 2009). "Tanshinone IIA protects against sudden cardiac death induced by lethal arrhythmias via repression of microRNA-1". British Journal of Pharmacology. 158 (5): 1227–35. PMID 19775284.
- Yan D, Dong X, Chen X, Wang L, Lu C, Wang J, et al. (October 2009). "MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development". The Journal of Biological Chemistry. 284 (43): 29596–604. PMID 19710019.
- Lu Y, Zhang Y, Shan H, Pan Z, Li X, Li B, et al. (December 2009). "MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotection". Cardiovascular Research. 84 (3): 434–41. PMID 19581315.
- Takaya T, Ono K, Kawamura T, Takanabe R, Kaichi S, Morimoto T, et al. (August 2009). "MicroRNA-1 and MicroRNA-133 in spontaneous myocardial differentiation of mouse embryonic stem cells". Circulation Journal. 73 (8): 1492–7. PMID 19521018.
- Tang Y, Zheng J, Sun Y, Wu Z, Liu Z, Huang G (May 2009). "MicroRNA-1 regulates cardiomyocyte apoptosis by targeting Bcl-2". International Heart Journal. 50 (3): 377–87. PMID 19506341.
- Shan ZX, Lin QX, Fu YH, Deng CY, Zhou ZL, Zhu JN, et al. (April 2009). "Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction". Biochemical and Biophysical Research Communications. 381 (4): 597–601. PMID 19245789.
- Mishima Y, Abreu-Goodger C, Staton AA, Stahlhut C, Shou C, Cheng C, et al. (March 2009). "Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization". Genes & Development. 23 (5): 619–32. PMID 19240126.
- Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, et al. (April 2009). "MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes". Molecular and Cellular Biology. 29 (8): 2193–204. PMID 19188439.
- Terentyev D, Belevych AE, Terentyeva R, Martin MM, Malana GE, Kuhn DE, et al. (February 2009). "miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2". Circulation Research. 104 (4): 514–21. PMID 19131648.
- Yu XY, Song YH, Geng YJ, Lin QX, Shan ZX, Lin SG, et al. (November 2008). "Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1". Biochemical and Biophysical Research Communications. 376 (3): 548–52. PMID 18801338.
- Sweetman D, Goljanek K, Rathjen T, Oustanina S, Braun T, Dalmay T, et al. (September 2008). "Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133" (PDF). Developmental Biology. 321 (2): 491–9. PMID 18619954.
- Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, Ghoshal K, Jacob ST (July 2008). "Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis". Cancer Research. 68 (13): 5049–58. PMID 18593903.
- Simon DJ, Madison JM, Conery AL, Thompson-Peer KL, Soskis M, Ruvkun GB, Kaplan JM, Kim JK (May 2008). "The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions". Cell. 133 (5): 903–15. PMID 18510933.
- Luo X, Lin H, Pan Z, Xiao J, Zhang Y, Lu Y, Yang B, Wang Z (July 2008). "Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart". The Journal of Biological Chemistry. 283 (29): 20045–52. PMID 18458081.
- Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, et al. (April 2007). "The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2". Nature Medicine. 13 (4): 486–91. S2CID 1935811.
- Mishima T, Mizuguchi Y, Kawahigashi Y, Takizawa T, Takizawa T (February 2007). "RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNS". Brain Research. 1131 (1): 37–43. S2CID 23792536.
- Nakajima N, Takahashi T, Kitamura R, Isodono K, Asada S, Ueyama T, Matsubara H, Oh H (December 2006). "MicroRNA-1 facilitates skeletal myogenic differentiation without affecting osteoblastic and adipogenic differentiation". Biochemical and Biophysical Research Communications. 350 (4): 1006–12. PMID 17045567.
- McCarthy JJ, Esser KA (January 2007). "MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy". Journal of Applied Physiology. 102 (1): 306–13. PMID 17008435.
- Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, et al. (February 2006). "The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation". Nature Genetics. 38 (2): 228–33. PMID 16380711.
- Kwon C, Han Z, Olson EN, Srivastava D (December 2005). "MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling". Proceedings of the National Academy of Sciences of the United States of America. 102 (52): 18986–91. PMID 16357195.
- Sokol NS, Ambros V (October 2005). "Mesodermally expressed Drosophila microRNA-1 is regulated by Twist and is required in muscles during larval growth". Genes & Development. 19 (19): 2343–54. PMID 16166373.
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- Bingham GE, Salisbury FB, Campbell WF, Carman JG, Bubenheim DL, Yendler B, et al. (1996). "The Spacelab-Mir-1 "Greenhouse-2" experiment". Advances in Space Research. 18 (4–5): 225–32. PMID 11538801.
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