miR-150
| miR-150 | |
|---|---|
Chr. 19 q13.33 | |
| PDB structures | PDBe |
miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
miR-150 functions in
erythrocytes.[3][4] It is also thought to control B and T cell differentiation, alongside miR-155.[5][6]
Role in cancer
miR-150 has been linked with a number of
gastric cancer and has also been found to be more than 50x overexpressed in osteosarcoma.[7]
Applications
miR-150 levels in blood plasma can be indicative of early
therapeutically in treating the condition.[8] In addition, miR-150 is one of a number of microRNAs whose expression profile could be used as a biomarker of hepatocellular carcinoma.[9]
References
Further reading
- Tsitsiou E, Lindsay MA (Aug 2009). "microRNAs and the immune response". Current Opinion in Pharmacology. 9 (4): 514–20. PMID 19525145.
- Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J (Oct 2012). "Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia". Cancer Cell. 22 (4): 524–35. PMID 23079661.