mir-765 microRNA precursor family

Source: Wikipedia, the free encyclopedia.
mir-765
Identifiers
Symbolmir-765
RfamRF01027
miRBase familyMIPF0000545
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

In molecular biology mir-765 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Traumatic Brain Injury

miR-765 has been identified as a diagnostic marker for traumatic brain injury (TBI), due to significantly elevated levels in the plasma of TBI patients. Furthermore, combination with either miR-16 or miR-92a allows extremely accurate distinction between TBI patients and healthy controls.[1]

miR-765 and pheochromocytomas

Increased miR-765 expression is observed in

neurotrophic tyrosine kinase receptor type 3 (NTRK3) gene. A NTRK3 3'UTR variant, ss102661458, is located in a functional target site of miR-765 and is able to significantly affect miRNA-mediated NTRK3 regulation. Through this there is restoration of the altered gene expression by miR-765. NTRK3 is underexpressed with high or overexpressed levels of miR-765, thus pointing towards a possible involvement of this relationship in pheochromocytoma pathogenesis.[3]

See also

References

Further reading

External links