mir-939 microRNA precursor family
| mir-939 | |
|---|---|
| Identifiers | |
| Symbol | mir-939 |
| Rfam | RF00981 |
| miRBase family | MIPF0000490 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-939 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Human inducible Nitric Oxide Synthase
miR-939 directly regulates and
transcription whilst also increasing miR-939 levels.[1]
Two functional binding sites within the hiNOS 3'UTR are essential for miR-939-mediated translational blockade and miR-939 has been shown to decrease cytokine-induced hiNOS expression, despite hiNOS mRNA levels and stability remaining unaffected. It has further been found that endogenous miR-939 expression in the liver may be induced by cytokines.
See also
References
- PMID 22451906.
Further reading
- Semaan, N.; Frenzel, L.; Alsaleh, G.; Suffert, G.; Gottenberg, J. E.; Sibilia, J.; Pfeffer, S.; Wachsmann, D. (2011). El Khoury, Joseph (ed.). "MiR-346 Controls Release of TNF-α Protein and Stability of Its mRNA in Rheumatoid Arthritis via Tristetraprolin Stabilization". PLOS ONE. 6 (5): e19827. PMID 21611196.
- Nymark, P.; Guled, M.; Borze, I.; Faisal, A.; Lahti, L.; Salmenkivi, K.; Kettunen, E.; Anttila, S.; Knuutila, S. (2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer". Genes, Chromosomes and Cancer. 50 (8): 585–597. S2CID 39556202.
External links
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