mir-101 microRNA precursor family
| mir-101 microRNA precursor family | |
|---|---|
| SO | SO:0001244 |
| PDB structures | PDBe |
miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739)[1] and mouse (MI0000148).[2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.
Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.[3]
References
Further reading
- He XP, Shao Y, Li XL, Xu W, Chen GS, Sun HH, Xu HC, Xu X, Tang D, Zheng XF, Xue YP, Huang GC, Sun WH (November 2012). "Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth". The FEBS Journal. 279 (22): 4201–12. S2CID 205132426.
External links
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