miR-224
| miR-224 | |
|---|---|
Chr. X q28 | |
| PDB structures | PDBe |
miR-224 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1]
Function
miR-224, being located on the
mRNA level is unchanged, increased miR-224 expression decreases concentration of SMDA4 protein in murine granulosa cells.[3] This is consistent with post-transcriptional miRNA regulation.[2]
Role in cancer
miR-224 has been noted as the most upregulated microRNA in hepatocellular carcinoma.[4] The same study identified a target of mir-224 as apoptosis-inhibitor 5 (API-5).[4]
miR-224 has also been linked with
CD40 expression in cancer cells.[5]