miR-338
| miR-338 | |
|---|---|
Chr. 17 q25.3 | |
| PDB structures | PDBe |
miR-338 is a family of brain-specific microRNA precursors found in mammals, including humans.[1] The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[2] This sequence then associates with RISC which effects RNA interference.[3]
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted that it may downregulate genes which have a downstream negative effect on AATK expression.[4]
Function
miR-338 is a
mRNA. This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing.[5]
Applications
miR-338 is dysregulated in
gastric cancer.[8]
References
Further reading
- He QY, Peng GP, Liu WX, Luo BY (Nov 2010). "[Interaction of microRNA-338 and its potential targeting protein eiF4E3]". Zhejiang da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 39 (6): 583–8. PMID 21166051.) (Chinese)
{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link - Saba R, Goodman CD, Huzarewich RL, Robertson C, Booth SA (2008). Akbarian S (ed.). "A miRNA signature of prion induced neurodegeneration". PLOS ONE. 3 (11): e3652. PMID 18987751.
External links