mir-16 microRNA precursor family
| mir-16 | ||
|---|---|---|
OMIM 609704 | | |
| Other data | ||
| RNA type | microRNA | |
| Domain(s) | Eukaryota; | |
| PDB structures | PDBe | |
The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, miR-15, mir-195 and miR-497 are related microRNA precursor sequences from the mir-15 gene family ([1]). This microRNA family appears to be vertebrate specific and its members have been predicted or experimentally validated in a wide range of vertebrate species (MIPF0000006).
Background
The
gene cluster which encodes the homologue to the human miR15 and miR16 from the Caenorhabditis elegans.[12][13][14]
Gene targets
In the original publication which identified the action of miR15 and miR16 in the development of
evolutionarily conserved pathway in programmed cell death.[19] In the nasopharyngeal carcinoma cell line, miR-16 has been shown to target the 3' UTR of vascular endothelial growth factor (VEGF) and repress the expression of VEGF, which is an important angiogenic factor.[20][21]
Clinical relevance
Altered expression of microRNA-16 has been observed in
expression profile has led to the proposal that disease specific biomarkers can provide potential targets for directed clinical intervention.[39] More recently, there is evidence that in colorectal cancer that the efficacy of treatment with the monoclonal antibody cetuximab can be assessed by the expression pattern of colorectal carcinoma after therapy.[40]
miR-16 and miR-15a are clustered within a 0.5
therapeutic
intervention.
References
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{{cite journal}}: CS1 maint: multiple names: authors list (link - ^ PMID 11264177.
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- S2CID 37265481.
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Further reading
[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21] [22] [23] [24] [25] [26] [27] [28]
External links
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