Monoacylglycerol lipase
| acylglycerol lipase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| monoglyceride lipase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | MGLL | ||||||
Chr. 3 p13-q13.33 | |||||||
| |||||||
Monoacylglycerol lipase (EC 3.1.1.23; systematic name glycerol-ester acylhydrolase, also known as MAG lipase, acylglycerol lipase, MAGL, MGL or MGLL) is an enzyme that, in humans, is encoded by the MGLL gene.[1][2][3] MAGL is a 33-kDa, membrane-associated member of the serine hydrolase superfamily and contains the classical GXSXG consensus sequence common to most serine hydrolases. The catalytic triad has been identified as Ser122, His269, and Asp239.[2][4]
Function
- hydrolyses glycerol monoesters of long-chain fatty acids
It functions together with hormone-sensitive lipase (LIPE) to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol. MGLL may also complement lipoprotein lipase (LPL) in completing hydrolysis of monoglycerides resulting from degradation of lipoprotein triglycerides.[5]
Monoacylglycerol lipase is a key enzyme in the hydrolysis of the
Inhibitors
MAGL enzyme inhibitors (URB602, URB754, JZL184) produce cannabinoid behavioral effects in mice.[10]
Further examples include:[citation needed]
See also
- Endocannabinoid enhancer
- Endocannabinoid reuptake inhibitor
- Triacylglycerol lipase
- Fatty acid amide hydrolase
References
- Mentlein R, Heiland S, Heymann E (1980). "Simultaneous purification and comparative characterization of six serine hydrolases from rat liver microsomes". Arch. Biochem. Biophys. 200 (2): 547–59. PMID 6776896.
- Pope JL, McPherson JC, Tidwell HC (1966). "A study of a monoglyceride-hydrolyzing enzyme of intestinal mucosa". J. Biol. Chem. 241 (10): 2306–10. PMID 5916497.
External links
- Monoacylglycerol+lipases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.1.23
- Monoglyceride lipase (MGLL) Human Protein Atlas
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
