Inositol monophosphatase 1
| IMPA1 | |||
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Gene ontology | |||
| Molecular function |
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| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| Location (UCSC) | Chr 8: 81.66 – 81.69 Mb | Chr 3: 10.38 – 10.4 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Inositol monophosphatase 1 is an enzyme that in humans is encoded by the IMPA1 gene.[5][6]
Interacting partners
IMPA1 has been shown to interact with Bergmann glial S100B[7] and calbindin.[8][9]
Chemical inhibitors
L-690,330 is a competitive inhibitor of IMPase activity with very good activity in vitro however with limited bioavailability in vivo.[10] Due to its increased specificity compared to Lithium, L-690,330 has been used extensively in characterizing the results of IMPase inhibition in various cell culture models. L-690,488, a prodrug or L-690,330, has also been developed which has greater cell permeability. Treatment of cortical slices with L-690,488 resulted in accumulation of inositol demonstrating the activity of this inhibitor in tissue.[11]
Inhibition of IMPA1 activity can have
and other effects.Bipolar disorder
Initially it was noticed that several drugs useful in treatment of bipolar disorder such as
valproic acid had a common mechanism of action on enzymes in the phosphatidylinositol signalling pathway[14] and the inositol depletion hypothesis for the pathophysiology of bipolar disorder was suggested. Intensive research has so far not confirmed this hypothesis, partly because lithium can also act on a number of other enzymes in this pathway, complicating results from in vitro
studies.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000133731 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027531 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1377913.
- ^ "Entrez Gene: IMPA1 inositol(myo)-1(or 4)-monophosphatase 1".
- PMID 19593677.
- PMID 15809430.
- PMID 12176979.
- S2CID 23498954.
- PMID 8035344.
- PMID 19383941.
- PMID 16874097.
- S2CID 4302048.
Further reading
- Bone R, Springer JP, Atack JR (1992). "Structure of inositol monophosphatase, the putative target of lithium therapy". Proc. Natl. Acad. Sci. U.S.A. 89 (21): 10031–10035. PMID 1332026.
- Hallcher LM, Sherman WR (1981). "The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain". J. Biol. Chem. 255 (22): 10896–901. PMID 6253491.
- Bone R, Frank L, Springer JP, Pollack SJ, Osborne S, Atack JR, Knowles MR, McAllister G, Ragan CI (1994). "Structural analysis of inositol monophosphatase complexes with substrates". Biochemistry. 33 (32): 9460–9467. PMID 8068620.
- Bone R, Frank L, Springer JP, Atack JR (1994). "Structural studies of metal binding by inositol monophosphatase: evidence for two-metal ion catalysis". Biochemistry. 33 (32): 9468–9476. PMID 8068621.
- Ganzhorn AJ, Lepage P, Pelton PD, Strasser F, Vincendon P, Rondeau JM (1996). "The contribution of lysine-36 to catalysis by human myo-inositol monophosphatase". Biochemistry. 35 (33): 10957–10966. PMID 8718889.
- Parthasarathy L, Parthasarathy R, Vadnal R (1997). "Molecular characterization of coding and untranslated regions of rat cortex lithium-sensitive myo-inositol monophosphatase cDNA". Gene. 191 (1): 81–87. PMID 9210592.
- Sjøholt G, Molven A, Løvlie R, Wilcox A, Sikela JM, Steen VM (1997). "Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA)". Genomics. 45 (1): 113–122. PMID 9339367.
- Nemanov L, Ebstein RP, Belmaker RH, Osher Y, Agam G (1999). "Effect of bipolar disorder on lymphocyte inositol monophosphatase mRNA levels". The International Journal of Neuropsychopharmacology. 2 (1): 25–29. S2CID 16964945.
- Bahn JH, Kim AY, Jang SH, Lee BR, Ahn JY, Joo HM, Kan TC, Won MH, Kwon HY (2002). "Production of monoclonal antibodies and immunohistochemical studies of brain myo-inositol monophosphate phosphatase". Mol. Cells. 13 (1): 21–7. PMID 11911470.
- Atack JR, Schapiro MB (2002). "Inositol monophosphatase activity in normal, Down syndrome and dementia of the Alzheimer type CSF". Neurobiol. Aging. 23 (3): 389–396. S2CID 24701473.
- Berggard T, Szczepankiewicz O, Thulin E, Linse S (2003). "Myo-inositol monophosphatase is an activated target of calbindin D28k". J. Biol. Chem. 277 (44): 41954–41959. PMID 12176979.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. PMID 12477932.
- Sjøholt G, Ebstein RP, Lie RT, Berle JØ, Mallet J, Deleuze JF, Levinson DF, Laurent C, Mujahed M (2005). "Examination of IMPA1 and IMPA2 genes in manic-depressive patients: association between IMPA2 promoter polymorphisms and bipolar disorder". Mol. Psychiatry. 9 (6): 621–629. S2CID 28747842.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. S2CID 4427026.
- Ohnishi T, Ohba H, Seo KC, Im J, Sato Y, Iwayama Y, Furuichi T, Chung SK, Yoshikawa T (2007). "Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1". J. Biol. Chem. 282 (1): 637–646. PMID 17068342.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Inositol monophosphatase 1
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