Drugs secreted in the kidney

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Table of medication secreted in kidney
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This is a table of drugs that are secreted in the kidney.

Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.

Medication Location
base[1]
cation[2]
 Percentage excreted[3]
para-aminohippurate
 proximal tubule[4] Acid anion
furosemide proximal tubule[4] Acid anion 100-75
glucuronic acid-conjugates proximal tubule[4] Acid
glycine conjugates
 proximal tubule[4] Acid
indometacin proximal tubule[4] Acid anion
methotrexate proximal tubule[4] Acid 100-75
penicillin proximal tubule[4] Acid anion 75-50
(benzylpenicillin)
probenecid proximal tubule[4] Acid anion
sulphate conjugates proximal tubule[4] Acid
thiazide diuretics proximal tubule[4] Acid
uric acid proximal tubule[4] Acid
amiloride proximal tubule[4] Base cation
dopamine proximal tubule[4] Base
histamine proximal tubule[4] Base
mepacrine proximal tubule[4] Base
morphine proximal tubule[4] Base cation
pethidine proximal tubule[4] Base
quaternary ammonium compounds
 proximal tubule[4] Base
quinine proximal tubule[4] Base cation
5-hydroxytryptamine (serotonin) proximal tubule[4] Base
triamterene proximal tubule[4] Base
gentamicin 100-75
atenolol 100-75
digoxin 100-75
cimetidine cation 75-50
tetracycline 75-50
(oxytetracycline)
neostigmine 75-50
propantheline
 ~50
tubocurarine
 ~50
acetazolamide proximal tubule[5] anion
chlorothiazide proximal tubule[5] anion
saccharin proximal tubule[5] anion
salicylate
 proximal tubule[5] anion
atropine proximal tubule[5] cation
NMN
 proximal tubule[5] cation
paraquat proximal tubule[5] cation
procainamide proximal tubule[5] cation
tetraethylammonium proximal tubule[5] cation
chlorpromazine proximal tubule[5] cation

References

  1. ISBN 0-443-07145-4
    . Page 112
  2. ISBN 1-4160-2328-3
    . Page 802
  3. ISBN 0-443-07145-4
    . Page 113
  4. ^
    ISBN 0-443-07145-4
    . Page 112
  5. ^
    ISBN 1-4160-2328-3
    . Page 802
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