Basiliximab

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Basiliximab
CD25
Clinical data
Trade namesSimulect
AHFS/Drugs.comMonograph
MedlinePlusa612013
License data
Pregnancy
category
  • AU: D
Immunosuppressants
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life7.2 days
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC6378H9844N1698O1997S48
Molar mass143801.68 g·mol−1
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Basiliximab, sold under the brand name Simulect, is a

T cells.[2] It is used in combination with other medicines used to prevent organ rejection.[2][3]

The most common side effects (seen in more than 20% of patients) include constipation, urinary tract infections (infection of the structures that carry urine), pain, nausea (feeling sick), peripheral oedema (swelling), hypertension (high blood pressure), anemia (low red blood cell counts), headache, hyperkalaemia (high blood potassium levels), hypercholesterolaemia (high blood cholesterol levels), surgical wound complication, weight increase, increased serum creatinine (a marker of kidney problems), hypophosphataemia (low blood phosphate levels), diarrhea and upper respiratory tract infection (colds).[3]

Basiliximab was approved for medical use in the United States and in the European Union in 1998.[2][3][4]

Medical uses

Basiliximab is

indicated for the prophylaxis of acute organ rejection in de-novo allogeneic renal transplantation.[3] It is to be used concomitantly with ciclosporin for microemulsion- and corticosteroid-based immunosuppression, in people with panel reactive antibodies less than 80%, or in a triple maintenance immunosuppressive regimen containing ciclosporin for microemulsion, corticosteroids and either azathioprine or mycophenolate mofetil.[3]

Basiliximab is an

cyclosporin. No short-term side effects have been reported.[6]

Mechanism of action

Basiliximab competes with IL-2 to bind to the alpha chain subunit of the IL2 receptor on the surface of the activated T lymphocytes and thus prevents the receptor from signaling. This prevents T cells from replicating and also from activating B cells, which are responsible for the production of

antibodies, which would bind to the transplanted organ and stimulate an immune response against the transplant.[7][8]

Chemistry

It is a chimeric CD25 monoclonal antibody of the IgG1 isotype.[7][8]

History

It is a Novartis product and was approved by the Food and Drug Administration (FDA) in 1998.[9]

References

  1. FDA
    . Retrieved 22 October 2023.
  2. ^ a b c d e "Simulect- basiliximab injection, powder, for solution". DailyMed. 6 October 2022. Archived from the original on 6 October 2022. Retrieved 27 February 2023.
  3. ^ a b c d e f g "Simulect EPAR". European Medicines Agency. Archived from the original on 11 January 2022. Retrieved 27 February 2023. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
  4. ^ "Basiliximab Product Approval Information - Licensing Action". U.S. Food and Drug Administration (FDA). 20 February 2009. Archived from the original on 13 January 2017. Retrieved 27 February 2023.
  5. ^ MedlinePlus. Last Revised - 15 June 2012 Basiliximab Injection Archived 5 July 2016 at the Wayback Machine
  6. ISBN 3-540-00878-0
    .
  7. ^
    S2CID 3296555
    .
  8. ^ a b "Basiliximab label" (PDF). Food and Drug Administration. Archived (PDF) from the original on 22 February 2017. Retrieved 16 December 2019.
  9. S2CID 9745527. Archived
    from the original on 13 April 2021. Retrieved 5 June 2020.
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