Elsilimomab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Mouse |
| Target | IL-6 |
| Clinical data | |
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| Identifiers | |
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  (what is this?) (verify) | |
Elsilimomab (also known as B-E8) is a mouse monoclonal antibody.[1] B-E8 was developed by Diaclone,[2] a French company which produces many mouse monoclonal antibodies.
It (OPR-003) targets (and blocks)
Interleukin-6.[3]
It has undergone a number of early stage clinical trials, e.g. for
myeloma.[4]
It was used as a template to develop a high-affinity, antagonist, fully human
References
- ^ "WHO Drug Information" (PDF). Archived from the original (PDF) on October 16, 2009.
p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k-chain, dimer
- ^ "Datasheet B-E8 mAb". Diaclone.
- ^ "First Fully Human Anti-IL6 Antibody Under Development". Genetic Engineering & Biotechnology News. Oct 2006.
- ^ PMID 19934301.