Interleukin 5

Interleukin 5 (IL-5) is an

Function

Through binding to the

IL-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed.^[7] Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease.^[8]

As of 2019, there are two FDA-approved

Some hydroxyethylaminomethylbenzimidazole analogs have shown IL-5 inhibition in vitro.^[12]

Effect on eosinophils

Eosinophils are terminally differentiated

In Hodgkin lymphoma, the typically-observed eosinophilia is thought to be attributable to an increased production of IL-5.^[15]

Interactions

IL-5 has been shown to

The IL-5 receptor is composed of an α and a βc chain.[19] The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF).^[19][20] Glycosylation of the Asn196 residue of the Rα subunit appears to be essential for binding of IL-5.^[21]

References