Rovelizumab
CD18[1] | |
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| Trade names | LeukArrest |
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Rovelizumab, also known as LeukArrest and Hu23F2G, is a
The drug is a monoclonal antibody that suppresses white blood cells which become overly active during shock.[3][4] During testing, the number of patients given the drug was low because rovelizumab had to be delivered within four hours of the injury and consent was required.[4] The patient was often unconscious and relatives had to be reached to give consent.[4] In June 1998, Icos and many medical centers asked the United States Food and Drug Administration (FDA) to waive consent requirements in situations where the patient was at high risk of dying and relatives could not be reached.[4] While some medical ethicists opposed waiving consent, the FDA approved the proposal in August 1998 for five medical centers.[5][6]
Development of rovelizumab was halted in April 2000 when interim data from phase III clinical trials did not meet Icos' goals,
Multiple companies have tried to develop anti-
References
- ^ PMID 16100700.
- ^ a b Reed K (June 15, 1999). "Icos Shares Skid After Drug Fails Test in Treating Shock". The Seattle Times. p. C7. Retrieved January 10, 2009.
- ^ Ervin K (June 21, 1998). "Deep Pockets + Intense Research + Total Control = The Formula—Bothell Biotech Icos Keeps The Pipeline Full Of Promise". The Seattle Times. p. F1. Retrieved January 10, 2009.
- ^ The Seattle Post-Intelligencer. p. C1.
- ^ Lerner M (June 23, 1998). "HCMC Seeks Feedback On Plans To Test Trauma Drug; Doctors Hope to Test a Medicine That Could Save Lives of Patients Who Are Unable to Speak For Themselves". Star Tribune. p. 1A.
- ^ "Community consultation and public disclosure information for waiver of Informed Consent" (PDF). Food and Drug Administration. August 27, 1998. Retrieved January 12, 2009.
- ^ "Icos Halts Stroke-Drug Study After Late Results Disappoint". The Seattle Times. April 21, 2000. p. C6. Retrieved January 10, 2009.
- ^ S2CID 190257.