Calcium ATPase
| Calcium ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Ca2+ ATPase is a form of
- Plasma membrane Ca2+ ATPase (PMCA)
- Sarcoplasmic reticulum Ca2+ ATPase (SERCA)
Plasma membrane Ca2+ ATPase (PMCA)
Plasma membrane Ca2+ ATPase (PMCA) is a
The PMCA belongs to a family of
The PMCA is expressed in a variety of tissues, including the brain.[7]
Sarcoendoplasmic Reticulum Ca2+ ATPase (SERCA)
In myocytes (muscle cells) Ca2+ is normally sequestered (isolated) in a specialized form of endoplasmic reticulum (ER) called sarcoplasmic reticulum (SR). It is a Ca2+ ATPase that transfers Ca2+ from the cytosol of the cell to the lumen of the SR at the expense of ATP hydrolysis during muscle relaxation. In the skeletal muscles the calcium pump in the sarcoplasmic reticulum membrane works in harmony with similar calcium pumps in the plasma membrane. This ensures that the cytosolic concentration of free calcium in resting muscle is below 0.1 μM. The sarcoplasmic and endoplasmic reticulum calcium pumps are closely related in structure and mechanism, and both are inhibited by the tumor-promoting agent thapsigargin, which does not affect the plasma membrane Ca2+ pumps.
See also
References
- ^ PDB Molecule of the Month Calcium pump
- ^ nlm.nih.gov
- PMID 15351500.
- ^ PMID 11152753.
- PMID 1986387.
- PMID 15765049.
- PMID 17170045. 17170045. Archived from the originalon September 27, 2007.
External links
- Calcium+ATPase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- EC 7.2.2.10
- Overview at utoronto.ca
- Cation transporting ATPase family in Pfam
